Table 4 Cartilage matrix proteins and modifying enzymes upregulated in adult cartilage relative to neonatal cartilage

Cartilage intermediate layer protein

CILP

CX598636.1

5.96

0.0102

CX599486.1

7.83

0.0042

Cartilage oligomeric matrix protein

COMP

CX592689.1

2.53

0.0036

CX592951.1

2.25

0.0014

CX593277.1

2.09

0.0164

CX597915.1

2.63

0.0041

CX600749.1

2.43

0.0035

CX601142.1

2.29

0.0038

Fibronectin

FN1

CX594011.1

4.65

0.0075

CX596432.1

3.35

0.0192

CX598808.1

3.86

0.0313

CX600436.1

4.18

0.0024

CX601190.1

4.62

0.0017

CX602630.1

1.31

0.1717

peFN840

6.03

0.0013

peFN-C1

7.24

0.0018

Frizzled-related protein

FRZB

CX597477.1

3.53

0.0159

CX598716.1

3.82

0.0227

CX604177.1

2.70

0.0015

Heparan sulfate 3-O-sulfotransferase 3A1

HS3ST3A1

CX595901.1

2.61

0.0061

Matrix metalloproteinase 1 (collagenase)

MMP1

peMMP1

4.61

0.0080

Nexin-1

PN-1

CX604123.1

2.27

0.0071

Procollagen C-endopeptidase enhancer 2

PCOLCE2

CX597547.1

4.63

0.0041

CX601347.1

2.08

0.0036

CX604313.1

1.89

0.0013

CX605197.1

4.64

0.0322

CX605337.1

4.31

0.0038

Serine proteinase inhibitor, clade A, member 5

SERPINA5

CX598843.1

3.27

0.0038

Sulfatase 1

SULF1

CX596711.1

2.83

0.0043

Tissue inhibitor of metallopeptidase 2

TIMP2

CX605012.1

4.48

0.0050