Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice

Table 2 Number of events on which overall conclusions about the efficacy of gastrointestinal protection strategies were based in a systematic review [24]

	Number of events recorded
Outcome	Coxib	NSAID + PPI	NSAID + H2A
Serious gastrointestinal complications	226	3	1
Symptomatic ulcers	452	18	1
Endoscopic ulcer	522	281	250
Anaemia	464	none	1
Withdrawal due to gastrointestinal symptoms	2171	48	57

Data from Hooper et al, 2004 [24]. The numbers show the actual numbers of events reported for each outcome in the paper, and the bold numbers indicate those where event rates were significantly lower with the strategy used than with NSAID alone

ISSN: 1471-2474