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Table 3 Summary of immunology studies on photooxidized osteochondral xenografts

From: Immunogenicity of unprocessed and photooxidized bovine and human osteochondral grafts in collagen-sensitive mice

 

Unprocessed

Photooxidized

Macrophages, cells of the innate immune system (ref. 34)

++++++

+

Adaptive T cell response to bovine grafts (cellular)

+

-

Adaptive T cell response to human grafts (cellular)

-

-

Adaptive B cell response to bovine grafts (humoral) – IgG1, IgG2a, IgG

-

-

Adaptive B cell response to human grafts (humoral) – IgG1, IgG2a, IgG

-

+

Adaptive B cell response to bovine and human grafts (humoral) – IgM

++

++