Influences of obese (ob/ob) and diabetes (db/db) genotype mutations on lumber vertebral radiological and morphometric indices: Skeletal deformation associated with dysregulated systemic glucometabolism

Table 1 Comparison of genotype mutation-related deficiencies in C57BL/KsJ Mice

Genotype	Mutation	Characteristic	Syndrome Indices
(+/?)	Controls (Heterozygous Littermates)	None	Normal
(db/db)	Diabetes (Lepr^db)	Leptin Membrane Receptor (lf) Missense Mutation Defect (leptin insensitive)	Obese, Type 2 NIDDM (severe hyperglycemia & hyperinsulinemia)
(ob/ob)	Obese (Lep^ob)	Leptin Protein Deficient (leptin gene mutation; leptin sensitive)	Obese, Type 2NIDDM (Moderate glycemia & insulin insensitive)

Comparison between genotypic indices induced by the indicate mutations, relative to normal littermate controls, and the attributed protein expression deficits associated with metabolic syndrome expression complications when expressed on the C57BL/KsJ murine background strain. An age-related exacerbation of the severity of mutation-induced metabolic/structural complications occurs for each genotype mutation.

ISSN: 1471-2474