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Table 4 Pain scores (pain was scored on a visual analog scale where 0 = no pain and 100 = the highest possible pain level).

From: S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. [ISRCTN36233495]

   Baseline SAMe Celecoxib  
Variable N+ Mean (SD) Mean (SD) Mean (SD) Stdif
Pain Level Today
   Month 1 52 45.3 (23.8) 33.8* (24.0) 24.6* (23.9) -0.33*
   Month 2 52 46.1 (24.2) 24.0* (19.5) 24.4* (23.6) 0.01
Pain Level over the Past Month
   Month 1 52 56.7 (22.5) 44.1* (22.4) 32.5* (24.0) -0.42**
   Month 2 52 57.0 (23.4) 34.7* (22.7) 33.1* (22.8) -0.05
  1. Stdif: Standardized difference scores – positive numbers indicate a better response with SAMe. +Sample size is less than 57 due to missing data in either Phase 1 or Phase 2. *Difference between baseline and treatment is statistically significant (p < 0.05). ** Difference between SAMe and Celecoxib is statistically significant (p < 0.05).