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Table 2 Effects of Simvastatin and PTH on Mouse Femurs at 13 weeks as Determined by μCT*

From: Does simvastatin stimulate bone formation in vivo?

Parameter OVX T13 (n = 9) PTH T13 (n = 9) SVS T13 (n = 9) OVX vs. PTH p-value SVS vs. OVX p-value PTH vs. SVS p-value
Full BV/TV (%) 67 ± 3 76 ± 4 68 ± 2 <0.001 NS <0.001
Tb.BV/TV (%) 5 ± 4 21 ± 11 5 ± 4 <0.001 NS <0.001
Tb.Th (mm) 0.06 ± 0.01 0.09 ± 0.01 0.06 ± 0.01 <0.001 NS <0.001
Tb.Sp (mm) 0.62 ± 0.21 0.40 ± 0.24 0.66 ± 0.20 <0.05 NS 0.03
Tb.N (1/mm) 1.9 ± 0.9 3.1 ± 1.2 1.7 ± 0.7 0.02 NS <0.01
Tb.Conn (1/mm3) 5 ± 4 17 ± 10 3 ± 3 <0.01 NS <0.001
Ct.TV (mm3) 1.9 ± 0.1 2.0 ± 0.2 1.9 ± 0.1 NS NS NS
Ct.MV/TV (%) 49 ± 3 43 ± 6 49 ± 2 <0.01 NS <0.01
Ct.Th (mm) 0.26 ± 0.02 0.31 ± 0.03 0.27 ± 0.01 <0.001 NS <0.001
  1. * Data are presented as means ± standard deviation. Groups were compared by ANOVA with post-hoc Fisher least significant difference (LSD) method. All p-values are two-tailed. NS = not significant.