Table 2 Effects of Simvastatin and PTH on Mouse Femurs at 13 weeks as Determined by μCT*

Full BV/TV (%)

67 ± 3

76 ± 4

68 ± 2

<0.001

NS

<0.001

Tb.BV/TV (%)

5 ± 4

21 ± 11

5 ± 4

<0.001

NS

<0.001

Tb.Th (mm)

0.06 ± 0.01

0.09 ± 0.01

0.06 ± 0.01

<0.001

NS

<0.001

Tb.Sp (mm)

0.62 ± 0.21

0.40 ± 0.24

0.66 ± 0.20

<0.05

NS

0.03

Tb.N (1/mm)

1.9 ± 0.9

3.1 ± 1.2

1.7 ± 0.7

0.02

NS

<0.01

Tb.Conn (1/mm³)

5 ± 4

17 ± 10

3 ± 3

<0.01

NS

<0.001

Ct.TV (mm³)

1.9 ± 0.1

2.0 ± 0.2

1.9 ± 0.1

NS

NS

NS

Ct.MV/TV (%)

49 ± 3

43 ± 6

49 ± 2

<0.01

NS

<0.01

Ct.Th (mm)

0.26 ± 0.02

0.31 ± 0.03

0.27 ± 0.01

<0.001

NS

<0.001