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Table 2 Overview of experimental groups of mice and seveverity of vascular disease.

From: MCMV induces neointima in IFN-γR-/- mice: Intimal cell apoptosis and persistent proliferation of myofibroblasts

    Lesions*
Genetic MCMV   Intima Media Adventitia
IFN-γR-/- + Genetic   ++++ ++++
IFN-γR-/- + - ++ ++ ++
Wild type + + + + +
Wild type + - 0 0 0
Controls - -/+ 0 0 0
  1. MCMV = MCMV infection 4 months, IRR = whole body irradiation * = 0 – 4 + semi quantitative visual estimate. + = mild adventitial mononuclear cell infiltrate, no changes in the media or intima. ++ = significant adventitial inflammation also extending to the media, mild intimal thickening, +++ = in addition to adventitial and medial inflammation formation of neointima. ++++ = severe obliteration due to neointima formation in abdominal aorta, severe inflammation of adventitia and media characterized by breaks in the elastica. ¶ = wild type or IFN-γR-/- 129S mice receiving salivary gland homogenate from uninfected animals, + IRR in half.