MCMV induces neointima in IFN-γR-/- mice: Intimal cell apoptosis and persistent proliferation of myofibroblasts

Table 2 Overview of experimental groups of mice and seveverity of vascular disease.

MCMV = MCMV infection 4 months, IRR = whole body irradiation ^* = 0 – 4 + semi quantitative visual estimate. + = mild adventitial mononuclear cell infiltrate, no changes in the media or intima. ++ = significant adventitial inflammation also extending to the media, mild intimal thickening, +++ = in addition to adventitial and medial inflammation formation of neointima. ++++ = severe obliteration due to neointima formation in abdominal aorta, severe inflammation of adventitia and media characterized by breaks in the elastica. ¶ = wild type or IFN-γR-/- 129S mice receiving salivary gland homogenate from uninfected animals, + IRR in half.

ISSN: 1471-2474