Figure 1

Radiographic features of COMP-MED (A, B, C) and of MATN3-MED (D, E, F). A: At 6 years of age, hip radiograph shows small and round femoral heads with irregular acetabular roof. B: At 12 years, the epiphysis at the knee joint is irregular and flattened. C: At 6 years, the hand radiograph shows brachymetacarpals, small and irregular carpal bones and distal radial epiphysis. D: At 6 years, the hip radiograph shows crescent shape femoral head with fragmentation and smooth acetabular roof. E: At 11 years of age, the vertical striations at the metaphysis are conspicuous along with irregular and flattened epiphysis. F: At age 6 years, the hand radiograph shows no brachymetacarpals or carpal bone irregularity. (This figure is partly a citation for images taken from “Revisit of Multiple Epiphyseal Dysplasia: Ethnic Difference in Genotypes and Comparison of Radiographic Features Linked to the COMP and MATN3 Genes” of the American Journal of Medical Genetics Part A. It is in the Nov 2011, Volume 155A, Issue 11:2669–2680 with permission).