Are outcomes after total knee arthroplasty worsening over time? A time-trends study of activity limitation and pain outcomes

Table 5 Subgroup Analyses of the time-trends in post-TKA moderate-severe ADL limitation and moderate-severe pain in 2002-05 compared to 1993-1995 by important patient characteristics

	Odds ratio (95% CI)	P-value	Odds ratio (95% CI)	P-value
	Age <65		Age ≥65
2- yr Overall Moderate-severe ADL limitation ¹	0.70 (0.41, 6.05)	0.19	1.43 (1.06, 1.95)	0.021
2- yr Mod- Severe Pain ¹	1.63 (0.77, 3.47)	0.20	1.81 (1.07, 3.07)	0.026
	No Psychological morbidity		Psychological morbidity
2- yr Overall Moderate- severe ADL limitation ²	1.50 (1.12, 2.00)	0.006	0.74 (0.29, 1.93)	0.54
2-yr Mod- Severe Pain ²	1.61 (1.02, 2.53)	0.039	3.82 (0.87, 16.7)	0.076
	BMI <30		BMI ≥30
2- yr Overall Moderate- severe ADL limitation ³	1.11 (0.75, 1.65)	0.60	1.36 (0.95, 1.95)	0.094
2- yr Mod- Severe Pain ³	1.44 (0.82, 2.53)	0.20	2.19 (1.11, 4.31)	0.023
	Deyo-Charlson index 0		Deyo-Charlson index 1 or higher
2- yr Overall Moderate- severe ADL limitation ⁴	1.48 (1.00, 2.20)	0.053	1.09 (0.76, 1.56)	0.62
2- yr Mod- Severe Pain ⁴	1.56 (0.88, 2.74)	0.125	2.16 (1.12, 4.15)	0.021

Psychological comorbidity was defined as the presence of anxiety, depression or both.
¹adjusted for age, sex, comorbidity, anxiety, depression, BMI, preoperative pain/function.
²adjusted for age, sex, comorbidity, BMI, preoperative pain/function (not adjusted for anxiety or depression, since the groups were stratified by its presence).
³adjusted for age, sex, comorbidity, anxiety, depression, BMI, preoperative pain/function (not adjusted for BMI, since the groups were stratified by BMI).
⁴adjusted for age, sex, anxiety, depression, BMI, preoperative pain/function (not adjusted for comorbidity, since the groups were stratified by Deyo-Charlson comorbidity score).
Bold indicates significant odds ratios.

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