Table 1 Summary of the OI patient cohort, medication data, and findings
Mild (type I) | Moderate (types IV, VI) | Severe (type III) | Total | |
|---|---|---|---|---|
Number of patients | 30 | 10 | 7 | 47 |
Age range at skull imaging (years) | 1.3-18.1 | 9.2-18.8 | 3.8-8.6 | 1.3-18.8 |
Mean height Z-score | -0.8 | -4.0 | -5.4 | -2.2 |
Number of patients treated with bisphosphonates | 18 | 8 | 4 | 30 |
Mean duration and range of bisphosphonate treatment prior to imaging (years) | 3.6 (0.1-8.3) | 3.2 (0.2-10.9) | 3.2(2.2-4) | 0.7 (0.1-10.9) |
Number of patients with hypermobile joints | 22 (73%) | 6 (60%) | 5 (71%) | 33 (70%) |
Number of patients with scoliosis | 3 (10%) | 5 (50%) | 4 (57%) | 12 (26%) |
Number of patients with cranial anomaly | 2 (6.7%) | 5 (50%) | 5 (71%) | 12 (26%) |