Figure 6

Effect of Etanercept in flares 2 and 3 versus administration in flare 3 alone. (A) A schematic representation of the dosing paradigm for groups tested in the multi-flare model of SCW. Inflammation and pain values were recorded in all groups throughout the study. Two separate cohorts underwent different dosing paradigms to investigate the response to single or repeated drug administration in each flare. (B) Effect on inflammation of prophylactic administration of etanercept in cohorts 1 and 2; (C) Corresponding AUC calculations for inflammation. (D) mechanical pain responses measured concurrently with inflammation in the same rats in cohorts 1 and 2. (E) Corresponding AUC calculations for the pain response. Effect of prophylactic administration of dexamethasone on inflammation and pain in both cohorts (6B-E). Values are mean ± SEM of n= 8 rats per group. *** = P<0.001 versus Non-Arthritic; ^^ = P<0.01 versus SCW; ^^^ = P<0.001 versus SCW.