Figure 4
Etanercept inhibits production of cytokines IL-6, IL-1β, MCP-1 and CINC-1 in the arthritic paw (flare 2). (A) Effect of etanercept (1 mg/kg prophylactically) on levels of Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6) and (B) Effect of etanercept (1 mg/kg prophylactically) on levels of Monocyte Chemotactic Protein-1 (MCP-1) and Cytokine-Induced Neutrophil Chemoattractant-1 (CINC-1) from ankle joint homogenates collected on day 22, 24 hours post induction of the flare 2. Values are mean ± SEM of 12–16 rats per group. * = P < 0.05 versus Non-Arthritic; *** = P < 0.001 versus Non-Arthritic; ^^^ = P<0.001 versus SCW. (P) prophylactic; (T) therapeutic.