Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects

Pan, Feng; Tian, Jing; Winzenberg, Tania; Ding, Changhai; Jones, Graeme

doi:10.1186/1471-2474-15-404

Table 1 Characteristics of individual studies included in meta-analysis

From: Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects

First author	Year	Country	Study design	Ethnicity	Sample size		Source of controls	Genotyping method	Age (mean)		Knee OA definition
					Case	Control			Case	Control	Radiographic*	Clinical^†	TKR
Southam^a	2007	UK	Case–control	Caucasian	349	822	HB	PCR-RFLP	65	69			+
Southam^b	2007	Spain	Case–control	Caucasian	274	1196	HB	TaqMan	NA	>55.0			+
Miyamoto^a	2007	Japan	Case–control	Asian	718	861	HB	TaqMan, Invader, DNA fragment analysis or Direct sequence	71.9	49.4	+
Miyamoto^b	2007	China	Case–control	Asian	313	485	HB	TaqMan, Invader, DNA fragment analysis or Direct sequence	58.8	56.8	+
Tsezou	2007	Greece	Case–control	Caucasian	251	268	HB	Direct sequence	67.9	65.2	+
Chapman	2008	Netherlands	Cohort study	Caucasian	142	724	PB	Mass spectrometry	60.4	59.6	+
Valdes^a	2009	UK	Case–control	Caucasian	735	654	HB	Allele-specific PCR	68.5	66.9		+
Valdes^b	2009	UK	Cohort study	Caucasian	264	512	PB	Allele-specific PCR	66.3	63	+
Vaes	2009	Netherlands	Cohort study	Caucasian	667	2097	PB	TaqMan	>55.0	>55.0	+
Evangelou^a	2009	Iceland	Cohort study	Caucasian	1071	1169	PB	Centaurus platform	74.8	74.8			+
Evangelou^b	2009	UK	Twins study	Caucasian	177	548	NA	Illumina platform	54.3	54.3	+
Evangelou^c	2009	Finland	Family-based study	Caucasian	109	209	NA	Mass spectrometry	67	58	+		+
Cao	2010	Korea	Case–control	Asian	276	298	PB	PCR-RFLP	63	44			+
Tawonsawatruk	2011	Thailand	Case–control	Asian	103	103	HB	PCR-RFLP	68.5	59.25			+
Valde^a	2011	UK	Cohort study	Caucasian	867	758	PB	Allele-specific PCR	66.5	66.5			+
Valdes^b	2011	Estonian	Cohort study	Caucasian	65	427	PB	Allele-specific PCR	47.1	47.1	+
Valdes^c	2011	UK	Cohort study	Caucasian	1141	536	PB	Allele-specific PCR	65.5	65.5	+		+
Valdes^d	2011	Netherlands	Cohort study	Caucasian	162	1582	PB	TaqMan	>45.0	>45.0	+
Shin	2012	Korea	Cohort study	Asian	725	1737	PB	High resolution melting analysis	67.4	62.7	+
Mhishra	2013	India	Case–control	Asian	300	300	HB	PCR-RFLP	54.0	55.2	+	+

^a,b,c and ^dDenote an independent study in the one article, respectively; NA Data not available; HB hospital-based; PB population-based; PCR-RFLP polymerase chain reaction restriction fragment length polymorphism; TKR total knee replacement.
*Radiographic criteria (Kellgren/Lawrence grade ≥2).
^†Clinical criteria are based on the American College of Rheumatology.

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ISSN: 1471-2474

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