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Table 2 Summary ORs and 95% CIs of TNF-α polymorphism and osteoarthritis

From: Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk

Analysis n Dominant model(GA + AA vs.GG) Recessive model(AA vs.GG + GA) A allele vs. G allele
OR(95% CI) P/Phet OR(95% CI) P/Phet OR(95% CI) P/Phet
Overall 7 2.45(0.95-6.27) 0.06/0.00 11.08(4.75-25.86) 0.00/0.25 2.30(1.08-4.90) 0.03/0.00
Ethnicity        
Caucasian 2 1.37(0.89-2.10) 0.14/0.92 6.99(0.70-69.68) 0.10/0.66 1.42(0.96-2.09) 0.08/0.89
Asian 3 4.35(0.91-20.92) 0.07/0.00 11.85(4.77-29.48) 0.00/0.07 3.59(1.06-12.18) 0.04/0.00
Study design       
 HCC 2 1.31(0.83-2.08) 0.24/0.89 6.99(0.70-69.68) 0.10/0.66 1.38(0.91-2.08) 0.13/0.79
 PCC 3 3.58(0.94-13.62) 0.06/0.00 11.85(4.77-29.48) 0.00/0.07 3.10(1.08-8.87) 0.04/0.00
Sample size       
Smaller 2 1.37(0.89-2.10) 0.14/0.92 6.99(0.70-69.68) 0.10/0.66 1.42(0.96-2.09) 0.08/0.89
Larger 3 4.35(0.91-20.92) 0.07/0.00 11.85(4.77-29.48) 0.00/0.07 3.59(1.06-12.18) 0.04/0.00
  1. n, number of studies in each analysis; HCC, Hospital based case–control study; PCC, population based case–control study; OR, odds ratio; CI, confi dence interval; p, p value for each test; Phet, p -value for heterogeneity test.