Table 2 Summary ORs and 95% CIs of TNF-α polymorphism and osteoarthritis
From: Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk
Analysis | n | Dominant model(GA + AA vs.GG) | Recessive model(AA vs.GG + GA) | A allele vs. G allele | |||
|---|---|---|---|---|---|---|---|
OR(95% CI) | P/Phet | OR(95% CI) | P/Phet | OR(95% CI) | P/Phet | ||
Overall | 7 | 2.45(0.95-6.27) | 0.06/0.00 | 11.08(4.75-25.86) | 0.00/0.25 | 2.30(1.08-4.90) | 0.03/0.00 |
Ethnicity | |||||||
Caucasian | 2 | 1.37(0.89-2.10) | 0.14/0.92 | 6.99(0.70-69.68) | 0.10/0.66 | 1.42(0.96-2.09) | 0.08/0.89 |
Asian | 3 | 4.35(0.91-20.92) | 0.07/0.00 | 11.85(4.77-29.48) | 0.00/0.07 | 3.59(1.06-12.18) | 0.04/0.00 |
Study design | |||||||
HCC | 2 | 1.31(0.83-2.08) | 0.24/0.89 | 6.99(0.70-69.68) | 0.10/0.66 | 1.38(0.91-2.08) | 0.13/0.79 |
PCC | 3 | 3.58(0.94-13.62) | 0.06/0.00 | 11.85(4.77-29.48) | 0.00/0.07 | 3.10(1.08-8.87) | 0.04/0.00 |
Sample size | |||||||
Smaller | 2 | 1.37(0.89-2.10) | 0.14/0.92 | 6.99(0.70-69.68) | 0.10/0.66 | 1.42(0.96-2.09) | 0.08/0.89 |
Larger | 3 | 4.35(0.91-20.92) | 0.07/0.00 | 11.85(4.77-29.48) | 0.00/0.07 | 3.59(1.06-12.18) | 0.04/0.00 |