Figure 1From: Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits Experimental design to study the effect of PAM on subchondral bone loss in ACLT- induced osteoarthritis. (a) Experimental scheme. (b) Typical Micro-CT images selected of a highly representative subchondral bone sample for each group. (A,B) Sham-operated group, (C) short-term treatment with PAM, (D) long-term treatment with PAM, (E-H) ACLT-induced osteoarthritis at 2, 4, 6 and 14 weeks. Marked differences in the microarchitecture of subchondral bone were observed.Back to article page