The discriminative ability of FRAX, the WHO algorithm, to identify women with prevalent asymptomatic vertebral fractures: a cross-sectional study

Table 1 Comparison between patients with and without vertebral fractures

	Group 0: Women without vertebral fractures N = 526	Group 1: Women with grade 1 vertebral fractures N = 203	Group 2: Women with grade 2 or 3 vertebral fractures N = 179	P-value 0 vs 2	P-value 0 vs 1	P-value 1 vs 2
Age (yrs): mean (SD)	59.1 (7.1)	60.7 (7.2)	66.5 (7.7)	<0.0001	0.037	<0.0001
Weight (Kgs): mean (SD)	74.4 (13.0)	74.5 (14.3)	68.5 (11.4)	<0.0001	NS	<0.0001
Height (m): mean (SD)	1.57 (0.06)	1.55 (0.06)	1.55 (0.06)	<0.0001	<0.0001	NS
Body Mass Index (Kg/m²): mean (SD)	30.0 (4.0)	30.7 (4.1)	28.4 (3.4)	<0.001	NS	<0.0001
Number of parity: mean (SD)	4.8 (2.3)	5.1 (2.5)	5.8 (3.1)	<0.0001	NS	NS
Years since menopause: mean (SD)	11.0 (8.2)	12.4 (8.5)	17.5 (9.4)	<0.0001	NS	<0.0001
Lumbar spine BMD (g/cm²): mean (SD)	0.998 (0.15)	0.945 (0.16)	0.873 (0.14)	<0.0001	<0.0001	<0.0001
Lumbar spine T-score: mean (SD)	-1.3 (1.2)	-1.7 (1.3)	-2.4 (1.2)	<0.0001	0.025	<0.0001
Femoral neck BMD (g/cm²): mean (SD)	0.925 (0.14)	0.878 (0.13)	0.830 (0.12)	<0.0001	0.002	0.049
Femoral neck T-score: mean (SD)	-0.7 (1.0)	-1.2 (1.1)	-1.6 (1.0)	<0.0001	0.003	0.003
Total hip BMD (g/cm²): mean (SD)	0.930 (0.14)	0.866 (0.13)	0.815 (0.12)	<0.0001	0.003	0.002
Total hip T-score: mean (SD)	-0.7 (1.0)	-1.2 (1.1)	-1.6 (1.0)	<0.0001	0.003	0.002
T ≤ -2.5 at anysite: n(%)	109 (20.7)	77 (37.9)	98 (54.7)	<0.0001	<0.0001	<0.0001
FRAX major fracture without BMD	2.1 (1.2)	2.2 (1.2)	3.5 (1.7)	<0.0001	NS	<0.0001
FRAX hip fracture without BMD	0.4 (0.5)	0.4 (0.4)	1.0 (0.8)	<0.0001	NS	<0.0001
FRAX major fracture with BMD	2.2 (3.1)	2.5 (1.5)	3.4 (1.7)	<0.0001	NS	0.002
FRAX hip fracture with BMD	0.4 (1.9)	0.5 (0.7)	0.9 (1.0)	<0.001	NS	0.024

Data as mean (SD) or number (percent). We performed pairwise comparisons among the 3 groups using the Bonferoni test after an analysis of variance ANOVA.

ISSN: 1471-2474