Figure 5
Influence of 1,25(OH) 2 D 3 therapy on trabecular bone volume, osteoid volume and cellular bone turnover parameters (secondary spongiosa of the third lumbar vertebra) in AIA of the rat. Vehicle-treated AIA was associated with a significant increase of osteoid-covered surface and osteoid-covered surface with osteoblasts (D; E) and a numerical increase in resorption surface with osteoclasts (C) in comparison with healthy controls. Trabecular bone volume and osteoid volume at the axial bone remained unaffected by AIA (A; B). 1,25(OH)2D3 therapy led to a highly significant increase of trabecular bone volume (A) and osteoid volume (B) in comparison to vehicle-treated AIA and healthy controls and resulted furthermore in a significant decrease in resorption surface with osteoclasts (C) and osteoid-covered surface with osteoblasts (E) in comparison to vehicle-treated AIA and reduced these parameters to the values of healthy controls. ***p < 0.001; *p < 0.05 vs. AIA + vehicle; +++p < 0.001; +p < 0.05 vs. healthy controls.