From: In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey
I Anulus fibrosus | |
Grade: | |
1 | Normal, pattern of fibrocartilage lamellae without ruptured fibers and without a serpentine appearance anywhere within the anulus |
2 | Ruptured or serpentine patterned fibers in less than 30% of the anulus |
3 | Ruptured or serpentine patterned fibers in more than 30% of the anulus |
II Border between the anulus fibrosus and nucleus pulposus | |
Grade: | |
1 | Normal |
2 | Minimally interrupted |
3 | Moderate/severe interruption |
III Cellularity of the nucleus pulposus | |
Grade: | |
1 | Normal cellularity with large vacuoles in the gelatinous structure of the matrix |
2 | Slight decrease in the number of cells and fewer vacuoles |
3 | Moderate/severe decrease (>50%) in the number of cells and no vacuoles |