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Table 1 Degeneration histologic grading scale

From: In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey

I Anulus fibrosus
Grade:  
1 Normal, pattern of fibrocartilage lamellae without ruptured fibers and without a serpentine appearance anywhere within the anulus
2 Ruptured or serpentine patterned fibers in less than 30% of the anulus
3 Ruptured or serpentine patterned fibers in more than 30% of the anulus
II Border between the anulus fibrosus and nucleus pulposus
Grade:  
1 Normal
2 Minimally interrupted
3 Moderate/severe interruption
III Cellularity of the nucleus pulposus
Grade:  
1 Normal cellularity with large vacuoles in the gelatinous structure of the matrix
2 Slight decrease in the number of cells and fewer vacuoles
3 Moderate/severe decrease (>50%) in the number of cells and no vacuoles