Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling

Table 2 Immunological and inflammatory profiles of AIA and K/BxN models

Compartment	Antigen-induced arthritis (AIA)	K/BxN serum-induced arthritis (KRN)
T cells	T cell-dependent [21, 22, 30]	T cell-independent [9]
B cells	B cell-independent [22]	B cell-independent [9]
Antibodies	Antibodies unnecessary/insufficient to induce arthritis to the full extent [21, 22, 30]	Antibodies necessary/sufficient to induce arthritis in full extent [9]
Complement	Complement-independent [31]	Complement-dependent [12]
Fc receptors	FcγR important [32, 33]	FcγR-dependent [12]
Neutrophils, macrophages	Neutrophils important [34, 35], but complement-independent [31]	Neutrophil-dependent, macrophage-dependent [13, 14]
Cytokines	IL-1, TNF-α, IL-6, IL-17, RANKL important [22, 36]	IL-1-, TNF-α-dependent [16] IL-6-, osteopontin-independent [16, 37]

ISSN: 1471-2474