Figure 1

Clinical assessment of inflammation in arthritic mice injected with mBSA and non-arthritic control mice. Arthritic mice were injected with mBSA on day 0 (AIA) and control mice were injected with phosphate buffered saline (CTR). (A) Means and SEM for knee joint swelling from day 1 to day 14 post intra-articular injection. Knee diameter was measured every 1–2 days and knee joint swelling was calculated as the difference to the knee diameter at day 0 (before arthritis induction) for each day. A repeated-measures analysis was performed (see Materials and Methods); the P _AIA value indicates the significance of the difference in variation of knee joint swelling over time between wild-type (WT) and transgenic (TG) mice treated with mBSA. (B) Means and SEM for knee joint swelling from day 1 to day 28, post intra-articular injection and three flare-up reactions induced by intravenous mBSA injections on days 7, 14, 21 (arrows). Knee diameter was measured every 1–2 days. The P _AIA value represents the significance derived by repeated-measures analysis between WT AIA mice and transgenic AIA mice.