Accuracy of vessel thickness determined with the digital vascular tree models. (A) 2D and 3D vessel thickness compared to the true value for different segmentation algorithms. LAT: local adaptive threshold, MS: multi-scale and GT: global threshold based segmentation. (B) Difference between measured and true vessel thickness (3D direct measurement) depending on vessel size. Results are averaged over all 10 models. (C) Distribution of true vessel thickness values in digital model compared to the results (3D direct measurement) of the three vessel segmentation algorithms. Results are shown for digital model number 1.