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Table 2 KIR gene distribution and its effect on MTX response

From: Presence of the full-length KIR2DS4 gene reduces the chance of rheumatoid arthritis patients to respond to methotrexate treatment

MTX response KIR genes
  2DS2 2DL3 2DL2 2DS3 2DL1 3DL1 3DS1 2DS5 2DS1 2DS4f* 2DS4d
Good responders (N = 179)
Presence (N) 107 155 103 68 178 171 59 52 71 55 156
Absence (N) 7 24 76 111 21 8 120 127 108 124 23
Frequency [%] 59.78 86.59 57.54 37.99 99.44 95.53 32.96 29.05 39.66 30.73 87.15
Poor responders (N = 133)
Presence (N) 75 121 71 33 129 121 46 41 55 50 110
Absence (N) 5 12 62 100 84 12 87 92 78 83 23
Frequency [%] 56.39 90.98 53.38 24.81 96.99 90.98 34.59 30.83 41.35 37.59 82.71
  1. *Good responders vs poor responders: p = 0.0334; OR = 0.43, 95%CI = 0.215-0.987.