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Figure 5 | BMC Musculoskeletal Disorders

Figure 5

From: Dose-dependent regulation of cell proliferation and collagen degradation by estradiol on ligamentum flavum

Figure 5

PI3K pathway was involved in the regulation of MMP-13 expression. Downstream signaling of MAPK pathway including p-ERK, p-JNK and p-38 was analyzed by Western blotting at 6 hours (A) and 24 hours (B) after the treatment of 10-9 M 17β-estradiol. No significant change was noted in comparison with control group. Up-regulation of expression of MMP-13 mRNA after the treatment of 10-9 M 17β-estradiol was attenuated by adding LY-294002, an inhibitor of PI3K (C). (E2: 17β-estradiol; LY: LY-294002).

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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