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Figure 4 | BMC Musculoskeletal Disorders

Figure 4

From: Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix deposition

Figure 4

Treated defects exhibit delayed collagen matrix deposition and strong neutrophil chemotaxis. Representative 1.25x magnification pictures from serial sagittal sections taken in the middle of the holes in the same rabbit knee showing treated defects after (A-C) 1 day (N=1) and (D-F) 21 days (N=4), and control defects after (G-I) 1 day (N=1) and (J- L) 21 days (N=4). Panels show collagen type I-positive, collagen type II-positive, and Safranin O-stained glycosaminoglycan tissues. White arrowheads: neutrophil-rich granulation tissue, black arrows: local fibroplasia in bone marrow below the proximal drill holes.

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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