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Table 4 Genotype frequencies of four polymorphisms in ONFH patients (total, idiopathic and secondary) and controls

From: Prevalence of genetic risk factors related with thrombophilia and hypofibrinolysis in patients with osteonecrosis of the femoral head in Poland

Genotype

Controls N=100

Patients

Total N=68

Idiopathic n=45

Secondary n=23

Factor V Leiden

GA

3(3%)

3(4,41%)

3(6,67%)

0

GG

97(97%)

65(95,59%)

42(93,33%)

23(100%)

Prothrombin

GA

2(2%)

1(1,47%)

0

1(4,35%)

GG

98(98%)

67(98,53%)

45(100%)

22(95,65%)

MTHFR

TT

7(7%)

4(5,88%)

4(8,89%)

0

CT

42(42%)

35(51,47%)

23(51,11%)

12(52,17%)

CC

51(51%)

29(42,65%)

18(40%)

11(47,83%)

TPA

DD

18(18%)

13(19,12%)

11(24,44%)a

2(8,7%)

ID

37(37%)

38(55,88%)b

24(53,33%)c

14(60,87%)

II

45(45%)

17(25%)

10(22,22%)

7(30,43%)

  1. a p=0,023; odds ratio (OR) 2,75; 95% confidence intervals (CIs) 0,99-7,95.
  2. bp=0,004 OR 2,71; 95% CIs 1,32-5,57.
  3. cp= 0,01; OR 2,91; 95% CIs 1,24-6,87.