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Table 3 Adjusted associations of BMI and activity (occupational/ leisure) at 36, 43, and 53 years with kOA in men

From: Body mass index, occupational activity, and leisure-time physical activity: an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort

 

36 years

43 years

53 years

 

OR

p-value

OR

p-value

OR

p-value

Manual occupation

0.98 (0.55, 1.76)

0.955

1.27 (0.74, 2.17)

0.386

2.03 (1.19, 3.49)

0.010

Non-manual occupation

Referent

 

Referent

 

Referent

 

BMI (per z-score)

1.22 (0.95, 1.56)

0.117

1.47 (1.14, 1.89)

0.003

1.44 (1.15, 1.82)

0.002

 p-value for test of interaction

 

0.350

 

0.232

 

0.758

Lifting unlikely

1.15 (0.62, 2.17)

0.654

0.71 (0.41, 1.24)

0.226

0.57 (0.33-0.99)

0.044

Lifting somewhat likely

Referent

 

Referent

 

Referent

 

Lifting highly likely

1.18 (0.57, 2.47)

0.659

0.62 (0.30, 1.27)

0.190

0.83 (0.43-1.60)

0.572

BMI (per z-score)

1.20 (0.93, 1.54)

0.153

1.41 (1.09, 1.81)

0.008

1.40 (1.10-1.77)

0.006

 p-value for test of interaction

 

0.133

 

0.011

 

0.745

Kneeling unlikely

1.17 (0.63, 2.15)

0.621

0.96 (0.54, 1.70)

0.887

0.60 (0.34-1.05)

0.072

Kneeling somewhat likely

Referent

 

Referent

 

Referent

 

Kneeling highly likely

0.93 (0.42, 2.07)

0.868

0.58 (0.26, 1.29)

0.180

0.76 (0.37-1.54)

0.446

BMI (per z-score)

1.19 (0.93, 1.53)

0.163

1.41 (1.09, 1.82)

0.008

1.39 (1.10-1.76)

0.006

 p-value for test of interaction

 

0.557

 

0.348

 

0.807

Sitting unlikely

0.92 (0.47, 1.77)

0.792

0.88 (0.49, 1.58)

0.670

1.00 (0.56-1.78)

0.999

Sitting somewhat likely

Referent

 

Referent

 

Referent

 

Sitting highly likely

1.13 (0.61, 2.06)

0.700

0.69 (0.39, 1.24)

0.226

0.60 (0.34-1.07)

0.085

BMI (per z-score)

1.19 (0.93, 1.53)

0.164

1.41 (1.09, 1.81)

0.008

1.42 (1.12-1.78)

0.004

 p-value for test of interaction

 

0.171

 

0.278

 

0.874

Inactive

1.47 (0.76, 2.86)

0.255

1.07 (0.62, 1.85)

0.800

1.77 (0.90-3.48)

0.095

Less active

Referent

 

Referent

 

Referent

 

Most active

1.59 (0.85, 2.96)

0.145

0.78 (0.42, 1.47)

0.447

1.44 (0.71-2.88)

0.309

BMI (per z-score)

1.31 (1.03, 1.66)

0.027

1.46 (1.16, 1.84)

0.001

1.42 (1.14-1.77)

0.002

 p-value for test of interaction

 

0.307

 

0.284

 

0.476

  1. OR Odds Ratio, BMI Body Mass Index.
  2. Note: separate models were examined for each activity exposure and BMI and coefficients reported are from models without a BMIxActivity interaction, adjusting for potential confounders - education at 26y, income at 53y, childhood social class, family history of arthritis, history of knee injury and health status at 53y. Where there was evidence for an interaction, Figures 1A and 1B show the full stratified odds ratios for BMI and activity in these models.
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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