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Figure 3 | BMC Musculoskeletal Disorders

Figure 3

From: Calpain 3 is important for muscle regeneration: Evidence from patients with limb girdle muscular dystrophies

Figure 3

Hematoxylin & eosin and neonatal myosin heavy chain stains are shown for patients with Limb-Girdle muscular dystrophy type 2A, patients with two CAPN3 null alleles (2NA), patients with Becker muscular dystrophy and patients with LGMD2I (A), (B). Asterisks denote whorled fibers. Bar is 100 μm. Comparison of internally nucleated fibers (INF) in patients with LGMD2A, those with two CAPN3 null alleles (2NA), BMD, and LGMD2I shows no difference among groups (C). In the same patient groups, the relationship between both nMHC and vimentin-positive fibers (black bars) and corresponding muscle strength of biopsied muscle, expressed as percentage of normal, (grey bars) is shown (D).

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