Vitamin D Receptor gene (VDR) transcripts in bone, cartilage, muscles and blood and microarray analysis of vitamin D responsive genes expression in paravertebral muscles of Juvenile and Adolescent Idiopathic Scoliosis patients

Table 3 Comparison of tissues from concave and convex side of the curve

Group	Isoform	Sample	Average	Median	Range	St. dev.	p
A	VDRl	B1	0	0	0
	VDRl	B2	0	0	0
	VDRs	B1	821	131	3 - 3018	1467	1.0
	VDRs	B2	734	643	70 -1579	780	1.0
B	VDRl	B1	0	0	0
	VDRl	B2	0	0	0
	VDRs	B1	174	30	2-746	270.3	0.28
	VDRs	B2	204	66	33-663	242.6	0.28
A	VDRl	C1	0	0	0
	VDRl	C2	0	0	0
	VDRs	C1	43754	193	7-252723	102440.5	0.72
	VDRs	C2	6901	98	89-34119	15213	0.72
B	VDRl	C1	0	0	0
	VDRl	C2	57	57	57
	VDRs	C1	981	92	4-6193	2300.6	0.66
	VDRs	C2	83	66	14-188	61.5	0.66
A	VDRl	M1	1493	218	56-5478	2661.3	0.64
	VDRl	M2	348	348	7-688	481.8	0.64
	VDRs	M1	3526	377	35-17817	6599.6	0.75
	VDRs	M2	1204203250.5	185	22-8429421053	3186021578.8	0.75
B	VDRl	M1	69	36	4-347	114.5	0.75
	VDRl	M2	56	43	3-132	44.6	0.75
	VDRs	M1	274	61	6-1649	482.7	0.50
	VDRs	M2	574	38	1-4902	1394,8	0.50

Comparison of QRT-PCR results between tissue samples obtained from concave and convex side of the scoliotic curve in group A – Juvenile Idiopathic Scoliosis (n=9) and group B-Adolescent Idiopathic Scoliosis (n=20). B1, C1, M1 adequately bone, articular cartilage and paravertebral tissue samples from concave side of the curve. B2, C2, M2 adequately bone, articular cartilage and paravertebral tissue samples from convex side of the curve, p<0,05 was considered as a statistically significant (nonparametric Mann Whitney U test).

ISSN: 1471-2474