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Table 1 Local graft treatment with bisphosphonate

From: Local treatment of a bone graft by soaking in zoledronic acid inhibits bone resorption and bone formation. A bone chamber study in rats

Study

Drug

Concentration

Soaking time

Rinse

Agholme 2009[13]

Alendronate

2mg/ml

10 min

3x3 min/no

Aspenberg 2002[10]

Alendronate

1 mg/ml

10 min

3x3 min

Baas 2008[11]

Pamidronate

9mg/ml

3 min

No

Belfrage 2011[6]

Zoledronate

0.5 mg/ml

Topical

No

Jakobsen 2007[14]

Alendronate

2 mg/ml

3 min

No

Jakobsen 2010[12]

Zoledronate

0.005/0.05/0.5 mg/ml

3 min

3 min

Jeppsson 2003[15]

Clodronate

60 mg/ml

10 min

3x3 min

Kesteris 2006[7]

Clodronate

60 mg/ml 10 ml

3 min

Washed 500 ml NaCl

Seo 2010[16]

Zoledronate

30 μM, 10 ml

5 min

No

Tägil 2004[5]

Alendronate

1 mg/ml

10 min

3x3 min

Tägil 2006[17]

Zoledronate

0.7 mg sc

*

-

  1. * Systemic injection of zoledronic acid to graft donor rat 24 hours before being euthanized.