Skip to main content

Table 1 Clinical and laboratory characteristics of AS patients and controls

From: Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis

  AS Patients (n =55) Controls (n = 33) p value
Age (years) 36 (19–61) 39 (23–48) 0.9
Sex (M/F) 48/7 24/9 0.1
BMI (kg/m 2 ) 25 (18–37) 25 (20–31) 0.9
Waist circumference (cm) 92 (66–120) 89 (65–104) 0.2
BMD-Lumbar spine (g/cm2) 0.9 (0.7–1.6) 1 (0.8–1.2) 0.1
BMD-Femoral neck (g/cm2) 0.8 (0.5–1.1) 0.9 (0.6–1.1) 0.002
ESR (mm/h) 17 (3–72) 9 (1–30) <0.0001
hs-CRP (mg/L) 8.5 (0.6–24.3) 2.5 (0–9.9) <0.0001
IL-6 (pg/mL) 18.5 (5–545) 8.1 (4–69) <0.0001
IFNγ (pg/mL) 0.002 (0.002–1.956) 0.002 (0.002–0.313) 0.5
BAP (U/L) 29 (13–107) 26 (2–51) 0.1
Calcium (mg/L) 10 (9–11) 9.9 (9.3–11) 0.7
Phosphor (mg/dL) 1.3 (1.7–4.7) 3.4 (2.2–4,5) 0.9
Vitamin D (nM) 87 (4–266) 102 (10–303) 0.5
NTX (nM, bone collagen equivalent) 82 (52–188) 84 (57–106) 0.3
TRAP 5 (U/L) 3.8 (2.3–6.6) 3.7 (2.3–8.34) 0.3
hPTH (pg/mL) 46 (44–170) 78 (45–180) 0.02
sRANKL (pmol/L) 284 (101–1598) 292 (143–783) 0.8
OPG (pg/mL) 339 (52–1118) 527 (16–1030) 0.02
sRANKL/OPG 0.99 (0.14-22.6) 0.65 (0.14–25.1) 0.04
Sclerostin (pmol/L) 73 (48–126) 77 (49–110) 0.2
sFRP1 (ng/mL) 0.14 (0.1–16.7) 0.2 (0.1–1.2) 0.4
DKK1 (pg/mL) 97 (17–771) 115 (29–278) 0.7
  1. Data are presented as the median with minimum and maximum values. ESR= erythrocyte sedimentation rate, hs-CRP= high sensitive C- reactive protein, IL-6= interleukin 6, IFNγ= interferon-gamma, BAP= bone-specific alkaline phosphatase, NTX= cross-linked N-telopeptide of type I collagen, TRAP 5= serum band 5 tartrate-resistant acid phosphatase, hPTH= human parathyroid hormone, sRANKL= soluble receptor activator of nuclear factor kappa-B ligand, OPG= osteoprotegerin, sFRP1= secreted frizzled-related protein 1, DKK1= Dickkopf-related protein 1.