Table 1 Clinical and laboratory characteristics of AS patients and controls
AS Patients (n =55) | Controls (n = 33) | p value | |
|---|---|---|---|
Age (years) | 36 (19–61) | 39 (23–48) | 0.9 |
Sex (M/F) | 48/7 | 24/9 | 0.1 |
BMI (kg/m 2 ) | 25 (18–37) | 25 (20–31) | 0.9 |
Waist circumference (cm) | 92 (66–120) | 89 (65–104) | 0.2 |
BMD-Lumbar spine (g/cm2) | 0.9 (0.7–1.6) | 1 (0.8–1.2) | 0.1 |
BMD-Femoral neck (g/cm2) | 0.8 (0.5–1.1) | 0.9 (0.6–1.1) | 0.002 |
ESR (mm/h) | 17 (3–72) | 9 (1–30) | <0.0001 |
hs-CRP (mg/L) | 8.5 (0.6–24.3) | 2.5 (0–9.9) | <0.0001 |
IL-6 (pg/mL) | 18.5 (5–545) | 8.1 (4–69) | <0.0001 |
IFNγ (pg/mL) | 0.002 (0.002–1.956) | 0.002 (0.002–0.313) | 0.5 |
BAP (U/L) | 29 (13–107) | 26 (2–51) | 0.1 |
Calcium (mg/L) | 10 (9–11) | 9.9 (9.3–11) | 0.7 |
Phosphor (mg/dL) | 1.3 (1.7–4.7) | 3.4 (2.2–4,5) | 0.9 |
Vitamin D (nM) | 87 (4–266) | 102 (10–303) | 0.5 |
NTX (nM, bone collagen equivalent) | 82 (52–188) | 84 (57–106) | 0.3 |
TRAP 5 (U/L) | 3.8 (2.3–6.6) | 3.7 (2.3–8.34) | 0.3 |
hPTH (pg/mL) | 46 (44–170) | 78 (45–180) | 0.02 |
sRANKL (pmol/L) | 284 (101–1598) | 292 (143–783) | 0.8 |
OPG (pg/mL) | 339 (52–1118) | 527 (16–1030) | 0.02 |
sRANKL/OPG | 0.99 (0.14-22.6) | 0.65 (0.14–25.1) | 0.04 |
Sclerostin (pmol/L) | 73 (48–126) | 77 (49–110) | 0.2 |
sFRP1 (ng/mL) | 0.14 (0.1–16.7) | 0.2 (0.1–1.2) | 0.4 |
DKK1 (pg/mL) | 97 (17–771) | 115 (29–278) | 0.7 |