Table 2 Biological pathways associated with SSKB genes

1

Allograft rejection

23

76.02

3.62E-39

6.82E-38

2

Intestinal immune network for IgA production

27

67.82

7.26E-44

2.05E-42

3

Asthma

14

58.61

4.14E-22

2.75E-21

4

Type I diabetes mellitus

20

57.09

9.13E-31

9.38E-30

5

Graft-versus-host disease

18

53.83

3.21E-27

2.79E-26

6

Autoimmune thyroid disease

22

52.13

1.29E-32

1.82E-31

7

Primary immunodeficiency

14

50.24

6.38E-21

3.79E-20

8

Hematopoietic cell lineage

33

47.1

1.39E-46

5.24E-45

9

Toll-like receptor signaling pathway

37

46.01

1.13E-51

6.38E-50

10

Apoptosis

25

35.68

5.55E-32

6.97E-31

11

NOD-like receptor signaling pathway

17

34.44

7.61E-22

4.78E-21

12

Amyotrophic lateral sclerosis (ALS)

14

33.18

5.81E-18

2.85E-17

13

Other glycan degradation

4

31.4

6.67E-06

1.24E-05

14

Cytokine-cytokine receptor interaction

66

31.05

5.91E-79

6.68E-77

15

T cell receptor signaling pathway

26

30.24

4.12E-31

4.66E-30

16

RIG-I-like receptor signaling pathway

17

30.07

9.98E-21

5.64E-20

17

Cell adhesion molecules (CAMs)

32

29.99

6.40E-38

1.03E-36

18

Bladder cancer

10

29.9

1.06E-12

3.24E-12

19

Viral myocarditis

17

29.25

1.68E-20

9.04E-20

20

Cytosolic DNA-sensing pathway

13

29.16

5.78E-16

2.42E-15

21

Pancreatic cancer

15

26.17

1.88E-17

8.50E-17

22

Small cell lung cancer

16

23.92

7.32E-18

3.45E-17

23

Glycosaminoglycan degradation

4

23.92

2.13E-05

3.65E-05

24

Natural killer cell mediated cytotoxicity

25

22.92

1.06E-26

8.56E-26

25

ErbB signaling pathway

13

22.16

2.51E-13

8.86E-13

26

Epithelial cell signaling in Helicobacter pylori infection

12

22.16

2.64E-13

9.04E-13

27

Complement and coagulation cascades

12

21.84

3.17E-13

1.05E-12

28

B cell receptor signaling pathway

13

21.77

3.38E-14

1.23E-13

29

Prion diseases

6

21.53

3.27E-07

6.84E-07

30

Antigen processing and presentation

15

21.17

5.49E-16

2.39E-15

31

Colorectal cancer

14

20.93

6.14E-15

2.48E-14

32

Adipocytokine signaling pathway

11

20.62

6.05E-12

1.80E-11

33

Chemokine signaling pathway

30

19.83

7.80E-30

7.35E-29

34

Prostate cancer

14

19.76

1.42E-14

5.53E-14

35

Glioma

10

19.32

1.10E-10

2.89E-10

36

Jak-STAT signaling pathway

23

18.64

1.67E-22

1.18E-21

37

Non-small cell lung cancer

8

18.61

1.13E-08

2.50E-08

38

Melanoma

10

17.69

2.71E-10

6.96E-10

39

Pathways in cancer

46

17.51

9.85E-43

2.23E-41

40

Fc epsilon RI signaling pathway

11

17.49

3.90E-11

1.05E-10

41

Chronic myeloid leukemia

10

16.75

4.74E-10

1.19E-09

42

GnRH signaling pathway

12

14.92

3.42E-11

9.43E-11

43

Leukocyte transendothelial migration

14

14.9

7.91E-13

2.48E-12

44

VEGF signaling pathway

9

14.87

1.04E-08

2.35E-08

45

Hypertrophic cardiomyopathy (HCM)

10

14.78

1.67E-09

4.10E-09

46

p53 signaling pathway

8

14.56

8.19E-08

1.75E-07

47

Endometrial cancer

6

14.49

3.65E-06

7.11E-06

48

Systemic lupus erythematosus

16

14.35

3.27E-14

1.23E-13

49

MAPK signaling pathway

30

14.01

3.15E-25

2.37E-24

50

Focal adhesion

22

13.75

1.21E-18

6.21E-18

51

Dilated cardiomyopathy

10

13.65

3.66E-09

8.44E-09

52

Type II diabetes mellitus

5

13.36

3.63E-05

6.12E-05

53

Neurotrophin signaling pathway

13

12.96

3.17E-11

8.96E-11

54

ECM-receptor interaction

8

11.96

3.85E-07

7.91E-07

55

Alzheimer's disease

16

11.89

6.32E-13

2.04E-12

56

Lysosome

11

11.81

2.86E-09

6.73E-09

57

Arginine and proline metabolism

5

11.63

7.15E-05

0.0001

58

Renal cell carcinoma

6

10.77

2.09E-05

3.63E-05

59

Long-term depression

6

10.77

2.09E-05

3.63E-05

60

Long-term potentiation

6

10.77

2.09E-05

3.63E-05

61

Proteasome

4

10.47

0.0006

0.0009

62

Progesterone-mediated oocyte maturation

7

10.22

6.00E-06

1.15E-05

63

TGF-beta signaling pathway

7

10.11

6.48E-06

1.22E-05

64

Regulation of actin cytoskeleton

16

9.3

2.69E-11

7.79E-11

65

Calcium signaling pathway

13

9.17

2.36E-09

5.67E-09

66

Wnt signaling pathway

11

9.15

4.17E-08

9.06E-08

67

Gap junction

6

8.37

8.67E-05

0.0001

68

Cell cycle

8

7.85

9.32E-06

1.70E-05

69

Oocyte meiosis

7

7.71

3.80E-05

6.31E-05

70

Axon guidance

7

6.82

8.33E-05

0.0001

71

Endocytosis

10

6.72

2.93E-06

5.81E-06

72

Metabolic pathways

26

2.96

1.12E-06

2.26E-06