Figure 7
From: IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse
Gene expression of mdx treated relative to control-Ab treated gastrocnemius muscle. Insulin like growth factor (IGF1), Suppressor of cytokine signaling 3 (SOCS3), Tumor necrosis factor (TNF-alpha), and Interleukin 10 (IL-10) were measured in muscle samples of mdx mice treated with IL-6r mAb (blocks IL-6 signaling) or control Ab. Samples are normalized to GAPDH and the fold change from mdx control mice is presented. Independent t-tests examined statistical differences (* indicates p < 0.05). Data are means and bars represent SEM.