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Table 2 FIQ total scores and VAS subscales throughout the study (mean ± sd) (ES: effect sizes)

From: Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study

  baseline week 6 week 12 week 18 week 24 P
Total scores 78.6 ± 11.5 72.2 ± 14.4 68.6 ± 16.6*** 66.5 ± 18.1*** 65.2 ± 18.5*** <0.0001
ES   0.56 0.88 1.06 1.17  
Work 8.19 ± 1.4 7.44 ± 1.9* 7.21 ± 2.1** 7.17 ± 2.1** 6.77 ± 2.4*** <0.0001
ES   0.54 0.71 0.73 1.02  
Pain 8.46 ± 1.4 7.92 ± 1.3 7.51 ± 1.8** 7.33 ± 1.09** 7.05 ± 2.3*** <0.0001
ES   0.38 0.70 0.81 1.04  
Fatigue 8.72 ± 1.2 8.02 ± 1.9 7.92 ± 1.6** 7.97 ± 1.7** 7.55 ± 2.3*** <0.0001
ES   0.58 0.67 0.62 1.00  
Morning tiredness 8.85 ± 1.2 7.64 ± 2.4 7.63 ± 2.4** 7.51 ± 2.3** 7.17 ± 2.4*** <0.0001
ES   1.00 1.02 1.12 1.39  
Stiffness 8.44 ± 1.7 7.55 ± 2.5** 7.26 ± 2.6** 7.15 ± 2.6** 7.06 ± 2.5*** = 0.0006
ES   0.52 0.72 0.81 0.83  
Anxiety 8.31 ± 1.7 7.47 ± 2.7 6.99 ± 2.5** 7.03 ± 2.4** 6.96 ± 2.4** = 0.0006
ES   0.49 0.78 0.75 0.78  
Depression 7.90 ± 2.8 6.88 ± 2.9 7.01 ± 3.1 6.97 ± 2.7 6.85 ± 3.0 = 0.0754
ES   0.36 0.32 0.33 0.38  
  1. *: p < 0.5, **: p < 0.01 and ***: p < 0.001 in relation to baseline (Tukey's post-test). Bold: large effect sizes.