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Table 2 Synovial fluid biomarker concentrations (pg/μg of total protein) of osteoarthritic knees with and without effusion

From: Biochemical comparison of osteoarthritic knees with and without effusion

  Non-Effused (n = 11) Effused (n = 11)   
Biomarker Median (95% CI) Median (95% CI) p value r
IL-1β 0.000009
(0.000003 - 0.000023)
0.000012
(0.000006 - 0.000020)
0.714 -0.078
IL-10 0.000017
(0.000007 - 0.000039)
0.000054
(0.000037 - 0.000184)
0.003* -0.625
IL-13 0.000057
(0.000038 - 0.000173)
0.000047
(0.000034 - 0.000087)
0.670 -0.091
TIMP-1 0.519388
(0.000000 - 13.457844)
52.008696
(38.851239 - 80.618044)
< 0.001* -0.791
TIMP-2 0.340405
(0.000000 - 2.521999)
4.471101
(3.758427 - 5.662756)
0.002* -0.665
MMP-3 0.130385
(0.000000 - 6.931912)
81.236149
(0.000000 - 334.057639)
< 0.001* -0.819
OPG 0.000148
(0.000045 - 0.000281)
0.000104
(0.000116 - 0.000447)
0.224 -0.259
VEGF 0.001912
(0.000000 - 0.020470)
0.019389
(0.011830 - 0.033989)
0.013 -0.515
  1. Note: CI = confidence interval, r = effect size, IL = interleukin, TIMP = tissue inhibitor of metalloproteinase, MMP = matrix metalloproteinase, OPG = osteoprotegerin, and VEGF = vascular endothelial growth factor. * p ≤ 0.006 was considered significant.