Table 2 Summary of gene expression patterns regulated in joint-instability induced osteoarthritis progression in rats (slice#1)

Matrix Degradation

Aggrecanase I

4.3

2.1

2.5

1.6

2.6

4.2

1.7

2.9

2.3

3.2

MMP13

2.8

1.6

1.9

2.0

4.3

3.7

1.6

2.0

2.2

5.8

Chondrocyte differentiation

Collagen IIA

2.3

2.0

2.8

1.3

1.3

1.8

1.5

2.2

1.4

1.2

Sox 9

2.6

1.8

1.4

1.4

0.8

1.8

1.1

1.4

1.8

1.4

Angiogenesis

VEGF

1.3

2.1

1.6

1.8

1.1

1.7

1.3

1.8

1.3

1.6

CD31

2.1

3.1

1.6

1.8

1.4

2.2

2.0

1.9

1.4

2.3

KDR

1.3

3.2

1.3

1.3

1.1

1.4

2.2

1.3

1.2

1.3

Bone resorption

Cathepsin K

1.5

1.5

1.8

2.7

2.5

1.8

1.9

2.1

2.0

4.1

TRAP

Bone formation

Runx2/cbfa-1

0.7

1.0

1.1

1.8

1.2

0.9

0.9

1.5

1.8

2.0

Osterix

0.7

0.9

1.0

1.7

1.1

1.2

0.9

1.6

1.6

1.6

Bone sialoprotein

1.1

1.4

1.7

1.8

1.6

1.6

1.3

1.5

1.9

2.9

Osteopontin

1.3

1.3

1.9

1.5

1.8

1.7

1.1

1.8

2.4

4.1