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Figure 3 | BMC Musculoskeletal Disorders

Figure 3

From: Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

Figure 3

Temporal regulation of markers of chondrocyte differentiation in the surgically-induced models of OA. (A) Collagen IIA was increased by 2-fold in ACLT model at wk 1 relative to Sham. Expression levels peaked at 3-fold through wk 2 and 4 and returned to Sham levels in wk 6 and 10. (B) Sox 9 demonstrated a similar, those less striking pattern of expression. Sox 9 was upregulated at wk 1 in ACLT and returned to Sham levels in wk 6 and 10. The fold changes in Col IIA levels were significantly lower in ACLT+MMx as compared to those in ACLT model. All values are shown as mean ± SD.

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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