Figure 4
From: Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage
Effect of TAK242 on LPS or TN-C induced changes in primary human chondrocytes. Human chondrocytes were induced with 1000 ng/ml LPS or 10 μg/ml TN-C for 48 hours. TAK242 was present 2 hours prior to induction and during the induction period. TAK242 effects on TN-C or LPS induced A, IL-6; B, nitrate; and C, PGE2 release. The error bars indicate SD of averaged treatments (duplicate wells) from 3 donors. * indicates p < 0.05.