Table 3 Genotypes and allelic frequencies of PAI-1 gene polymorphisms between ONFH patients (n = 206) and controls (n = 251)
From: Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head
Position | Genotype/Allele | Controls, n (%) | Patients, n (%) | OR (95% CI) | p |
|---|---|---|---|---|---|
g.-844G/A | GG | 116(46.2) | 67(32.5) | 1* | 0.011 |
(rs2227631) | GA | 97(38.6) | 97(47.1) | 1.73(1.15-2.61) | |
AA | 38(15.1) | 42(20.4) | 1.91(1.12-3.26) | ||
G | 329(65.5) | 231(56.1) | 1* | 0.003 | |
A | 173(34.5) | 181(43.9) | 1.49(1.14-1.95) | ||
g.-6754G/5G | 5G5G | 46(18.3) | 29(14.1) | 1* | 0.073 |
(rs1799889) | 4G5G | 130(51.8) | 95(46.1) | 1.16(0.68-1.98) | |
4G4G | 75(29.9) | 82(39.8) | 1.73(0.99-3.04) | ||
5G | 222(44.2) | 153(37.1) | 1* | 0.030 | |
4G | 280(55.8) | 259(62.9) | 1.34(1.03-1.75) | ||
g.10700C/T | TT | 79(31.5) | 45(21.8) | 1* | 0.013 |
(rs11178) | CT | 116(46.2) | 93(45.1) | 1.41(0.89-2.22) | |
CC | 56(22.3) | 68(33.0) | 2.13(1.28-3.55) | ||
T | 274(54.6) | 183(44.4) | 1* | 0.002 | |
C | 228(45.4) | 229(55.6) | 1.50(1.16-1.95) |