Table 3 Effects of three months of treatment with either vehicle or PG873637 on sham operated or myocardial infracted rat body mass, fractional area contraction, ejection fraction, systolic area, systolic volume, diastolic area, diastolic volume, scar weight, lung weight, muscle mass and muscle absolute force (Po).
| Sham Vehicle 3 month | Sham PG873637 3 month | MI Vehicle 3 month | MI PG873637 3 month | |
|---|---|---|---|---|
| Number of animals | 7 | 7 | 10 | 9 |
|
Final body mass (grams) |
482.8 (6.8) |
476.8 (12.4) |
480.5 (6.1) |
487.4# (7.6) |
|
Final Fractional Area Contractions (%) |
63.4 (7.6) |
65.2 (6.5) |
21.7# (6.9) |
26.0# (3.2) |
|
Final Ejection Fraction (%) |
68.2 (8.6) |
72.6 (4.9) |
25.3# (7.5) |
30.5# (3.6) |
|
Final LV Systolic Area (centimeters2) |
18.5 (4.1) |
17.7 (3.8) |
86.7# (15.2) |
71.8# (13.1) |
|
Final LV Systolic Volume (milliliters) |
0.2 (0.1) |
0.2 (0.1) |
1.3# (0.3) |
1.0# (0.3) |
|
Final LV Diastolic Area (millimeters2) |
50.7 (5.0) |
51.1 (5.2) |
110.4# (14.7) |
97.3# (18.5) |
|
Final LV Diastolic Volume (milliliters) |
0.7 (0.1) |
0.7 (0.1) |
1.7# (0.3) |
1.5# (0.3) |
|
Final Scar Weight (grams) | NA | NA |
0.1 (0.0) |
0.1 (0.0) |
|
Final Lung Weight (grams) |
1.5 (0.1) |
1.5 (0.1) |
2.8# (0.9) |
2.2# (1.0) |
|
EDL mass (milligrams) |
189.9 (3.7) |
228.6* (6.5) |
191.0 (1.9) |
230.0* (5.8) |
|
EDL mass/body mass (milligram/gram) |
0.41 (0.01) |
0.47* (0.01) |
0.40 (0.01) |
0.47* (0.01) |
|
EDL Po (milliNewtons) |
3348.7 (78.9) |
3909.9* (71.7) |
3073.3# (96.3) |
3927.7* (52.6) |
|
EDL Po/body mass (milliNewton/gram) |
7.16 (0.13) |
8.09* (0.18) |
6.41# (0.24) |
8.12* (0.13) |
|
Soleus mass (milligrams) |
188.9 (3.2) |
222.4* (7.9) |
197.0 (2.6) |
222.4* (7.9) |
|
Soleus mass/body mass (milligram/gram) |
0.40 (0.01) |
0.46* (0.01) |
0.41 (0.01) |
0.45* (0.01) |
|
Soleus Po (milliNewtons) |
2033.6 (26.9) |
2420.9* (88.1) |
2177.5# (46.0) |
2444.7* (68.8) |
|
Soleus Po/body mass (milliNewton/gram) |
4.38 (0.08) |
4.99* (0.15) |
4.53 (0.09) |
5.06* (0.14) |