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Table 3 Effects of three months of treatment with either vehicle or PG873637 on sham operated or myocardial infracted rat body mass, fractional area contraction, ejection fraction, systolic area, systolic volume, diastolic area, diastolic volume, scar weight, lung weight, muscle mass and muscle absolute force (Po).

From: Treatment with a corticotrophin releasing factor 2 receptor agonist modulates skeletal muscle mass and force production in aged and chronically ill animals

  Sham Vehicle 3 month Sham PG873637 3 month MI Vehicle 3 month MI PG873637 3 month
Number of animals 7 7 10 9
Final body mass (grams) 482.8 (6.8) 476.8 (12.4) 480.5 (6.1) 487.4# (7.6)
Final Fractional Area Contractions (%) 63.4 (7.6) 65.2 (6.5) 21.7# (6.9) 26.0# (3.2)
Final Ejection Fraction (%) 68.2 (8.6) 72.6 (4.9) 25.3# (7.5) 30.5# (3.6)
Final LV Systolic Area (centimeters2) 18.5 (4.1) 17.7 (3.8) 86.7# (15.2) 71.8# (13.1)
Final LV Systolic Volume (milliliters) 0.2 (0.1) 0.2 (0.1) 1.3# (0.3) 1.0# (0.3)
Final LV Diastolic Area (millimeters2) 50.7 (5.0) 51.1 (5.2) 110.4# (14.7) 97.3# (18.5)
Final LV Diastolic Volume (milliliters) 0.7 (0.1) 0.7 (0.1) 1.7# (0.3) 1.5# (0.3)
Final Scar Weight (grams) NA NA 0.1 (0.0) 0.1 (0.0)
Final Lung Weight (grams) 1.5 (0.1) 1.5 (0.1) 2.8# (0.9) 2.2# (1.0)
EDL mass (milligrams) 189.9 (3.7) 228.6* (6.5) 191.0 (1.9) 230.0* (5.8)
EDL mass/body mass (milligram/gram) 0.41 (0.01) 0.47* (0.01) 0.40 (0.01) 0.47* (0.01)
EDL Po (milliNewtons) 3348.7 (78.9) 3909.9* (71.7) 3073.3# (96.3) 3927.7* (52.6)
EDL Po/body mass (milliNewton/gram) 7.16 (0.13) 8.09* (0.18) 6.41# (0.24) 8.12* (0.13)
Soleus mass (milligrams) 188.9 (3.2) 222.4* (7.9) 197.0 (2.6) 222.4* (7.9)
Soleus mass/body mass (milligram/gram) 0.40 (0.01) 0.46* (0.01) 0.41 (0.01) 0.45* (0.01)
Soleus Po (milliNewtons) 2033.6 (26.9) 2420.9* (88.1) 2177.5# (46.0) 2444.7* (68.8)
Soleus Po/body mass (milliNewton/gram) 4.38 (0.08) 4.99* (0.15) 4.53 (0.09) 5.06* (0.14)
  1. All data given with standard error of the mean in paranthesis. * - statistically significant (p < 0.05) versus appropriate vehicle control: # - statistically significant (p < 0.05) versus appropriate sham control.