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Table 2 Effect of 5 months of treatment with either vehicle or PG873637 on female sham or emphysemic (EMP) hamster final body mass, lung volume, right ventricular (RV) mass, muscle mass and muscle absolute force (Po).

From: Treatment with a corticotrophin releasing factor 2 receptor agonist modulates skeletal muscle mass and force production in aged and chronically ill animals

  Sham vehicle Sham PG873637 EMP vehicle EMP PG873637
Number of animals 6 6 9 11
Final body mass (grams) 148.7 (7.6) 162.3 (9.0) 149.8 (4.1) 142.2 (4.4)
Lung volume (milliliter) 2.3 (0.2) 2.4 (0.2) 5.4# (0.4) 5.2# (0.6)
Lung volume/body mass (milliliter/gram) 0.02 (0.00) 0.02 (0.00) 0.04# (0.00) 0.04# (0.01)
RV mass (milligrams) 115.7 (4.1) 109.6 (4.0) 145.5# (6.3) 159.7# (9.7)
RV mass/body mass (milligram/gram) 0.78 (0.06) 0.69 (0.02) 0.99# (0.06) 1.15# (0.08)
EDL mass (milligrams) 32.6 (2.2) 46.0* (3.8) 33.0 (1.5) 35.7 (1.4)
EDL mass/body mass (milligram/gram) 0.22 (0.01) 0.28* (0.02) 0.22 (0.01) 0.25* (0.01)
EDL Po (milliNewtons) 832.5 (45.1) 1229.2* (36.1) 837.6 (29.0) 1057.2* (40.8)
EDL Po/body mass (milliNewtons/gram) 5.57 (0.19) 7.70* (0.35) 5.63 (0.13) 7.44* (0.14)
Costal diaphragm mass (milligrams) 252.2 (15.8) 290.5 (16.8) 242.9 (5.8) 260.9 (10.6)
Costal diaphragm mass/body mass (milligrams/grams) 1.70 (0.09) 1.80 (0.05) 1.64 (0.03) 1.84* (0.04)
  1. All data are given as the mean with the standard error of the mean in parenthesis. * - statistically significant difference (p < 0.05) versus the appropriate vehicle control; # - statistically significant difference (p < 0.05) versus control animals (non-emphysemic).