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Table 1 Effects of 1 month or 3 months of treatment with either vehicle or PG873637 on female 24 month old F344 rat body mass, muscle mass, muscle absolute force (Po).

From: Treatment with a corticotrophin releasing factor 2 receptor agonist modulates skeletal muscle mass and force production in aged and chronically ill animals

 

Time 0

1 month vehicle

1 month PG873637

3 month vehicle

3 month PG873637

Number of animals

8

8

7

14

16

Final body mass

(grams)

281.6

(8.1)

269.4

(5.0)

252.0#

(4.2)

256.9#

(6.7)

252.0#

(5.1)

EDL mass

(milligrams)

91.9

(1.0)

89.0

(1.9)

101.2*#

(2.1)

89.4

(1.5)

101.3*#

(4.2)

EDL mass/body mass

(milligram/gram)

0.33

(0.00)

0.34

(0.01)

0.40*#

(0.01)

0.35#

(0.01)

0.40*#

(0.01)

EDL Po

(milliNewtons)

2025.2

(18.7)

1965.6

(36.6)

2199.3*#

(59.3)

1761.4#

(56.3)

2004.6(*p = 0.06)

(114.2)

EDL Po/body mass

(milliNewton/gram)

7.23

(0.09)

7.42

(0.11)

8.68*#

(0.30)

6.86

(0.19)

7.86*

(0.40)

Soleus mass

(milligrams)

79.8

(2.2)

82.6

(2.1)

89.0#

(3.2)

81.3

(2.0)

88.3

(4.0)

Soleus mass/body mass

(milligram/gram)

0.28

(0.01)

0.31#

(0.01)

0.35*#

(0.01)

0.32#

(0.01)

0.35(*p = 0.06)#

(0.01)

Soleus Po

(milliNewtons)

1188.3

(24.6)

1244.5

(28.6)

1362.5*#

(45.3)

1128.1

(45.2)

1278.2

(81.3)

Soleus Po/body mass

(milliNewton/gram)

4.25

(0.08)

4.71#

(0.10)

5.37*#

(0.20)

4.39

(0.16)

5.03(*p = 0.06)#

(0.29)

  1. All data are given as the mean with the standard error of the mean in parenthesis. * - statistically significant difference (p < 0.05) versus the appropriate vehicle control; # - statistically significant difference (p < 0.05) versus Time 0.