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Table 1 Effects of 1 month or 3 months of treatment with either vehicle or PG873637 on female 24 month old F344 rat body mass, muscle mass, muscle absolute force (Po).

From: Treatment with a corticotrophin releasing factor 2 receptor agonist modulates skeletal muscle mass and force production in aged and chronically ill animals

  Time 0 1 month vehicle 1 month PG873637 3 month vehicle 3 month PG873637
Number of animals 8 8 7 14 16
Final body mass (grams) 281.6 (8.1) 269.4 (5.0) 252.0# (4.2) 256.9# (6.7) 252.0# (5.1)
EDL mass (milligrams) 91.9 (1.0) 89.0 (1.9) 101.2*# (2.1) 89.4 (1.5) 101.3*# (4.2)
EDL mass/body mass (milligram/gram) 0.33 (0.00) 0.34 (0.01) 0.40*# (0.01) 0.35# (0.01) 0.40*# (0.01)
EDL Po (milliNewtons) 2025.2 (18.7) 1965.6 (36.6) 2199.3*# (59.3) 1761.4# (56.3) 2004.6(*p = 0.06) (114.2)
EDL Po/body mass (milliNewton/gram) 7.23 (0.09) 7.42 (0.11) 8.68*# (0.30) 6.86 (0.19) 7.86* (0.40)
Soleus mass (milligrams) 79.8 (2.2) 82.6 (2.1) 89.0# (3.2) 81.3 (2.0) 88.3 (4.0)
Soleus mass/body mass (milligram/gram) 0.28 (0.01) 0.31# (0.01) 0.35*# (0.01) 0.32# (0.01) 0.35(*p = 0.06)# (0.01)
Soleus Po (milliNewtons) 1188.3 (24.6) 1244.5 (28.6) 1362.5*# (45.3) 1128.1 (45.2) 1278.2 (81.3)
Soleus Po/body mass (milliNewton/gram) 4.25 (0.08) 4.71# (0.10) 5.37*# (0.20) 4.39 (0.16) 5.03(*p = 0.06)# (0.29)
  1. All data are given as the mean with the standard error of the mean in parenthesis. * - statistically significant difference (p < 0.05) versus the appropriate vehicle control; # - statistically significant difference (p < 0.05) versus Time 0.