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Table 1 Effects of 1 month or 3 months of treatment with either vehicle or PG873637 on female 24 month old F344 rat body mass, muscle mass, muscle absolute force (Po).

From: Treatment with a corticotrophin releasing factor 2 receptor agonist modulates skeletal muscle mass and force production in aged and chronically ill animals

  Time 0 1 month vehicle 1 month PG873637 3 month vehicle 3 month PG873637
Number of animals 8 8 7 14 16
Final body mass
(grams)
281.6
(8.1)
269.4
(5.0)
252.0#
(4.2)
256.9#
(6.7)
252.0#
(5.1)
EDL mass
(milligrams)
91.9
(1.0)
89.0
(1.9)
101.2*#
(2.1)
89.4
(1.5)
101.3*#
(4.2)
EDL mass/body mass
(milligram/gram)
0.33
(0.00)
0.34
(0.01)
0.40*#
(0.01)
0.35#
(0.01)
0.40*#
(0.01)
EDL Po
(milliNewtons)
2025.2
(18.7)
1965.6
(36.6)
2199.3*#
(59.3)
1761.4#
(56.3)
2004.6(*p = 0.06)
(114.2)
EDL Po/body mass
(milliNewton/gram)
7.23
(0.09)
7.42
(0.11)
8.68*#
(0.30)
6.86
(0.19)
7.86*
(0.40)
Soleus mass
(milligrams)
79.8
(2.2)
82.6
(2.1)
89.0#
(3.2)
81.3
(2.0)
88.3
(4.0)
Soleus mass/body mass
(milligram/gram)
0.28
(0.01)
0.31#
(0.01)
0.35*#
(0.01)
0.32#
(0.01)
0.35(*p = 0.06)#
(0.01)
Soleus Po
(milliNewtons)
1188.3
(24.6)
1244.5
(28.6)
1362.5*#
(45.3)
1128.1
(45.2)
1278.2
(81.3)
Soleus Po/body mass
(milliNewton/gram)
4.25
(0.08)
4.71#
(0.10)
5.37*#
(0.20)
4.39
(0.16)
5.03(*p = 0.06)#
(0.29)
  1. All data are given as the mean with the standard error of the mean in parenthesis. * - statistically significant difference (p < 0.05) versus the appropriate vehicle control; # - statistically significant difference (p < 0.05) versus Time 0.