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Figure 6 | BMC Musculoskeletal Disorders

Figure 6

From: Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor

Figure 6

Kinase inhibitor effects on VEGF, IL-8, and MMP-9 production by THP1 macrophages (n = 4). Differentiated THP-1 cells were stimulated for 48 hours with LPS and pretreated with different concentrations of inhibitors of ERK, PI3K, and CAMKII pathways. PD = PD98059-MEK inhibitor, LY = LY294002-PI3K inhibitor, KN = KN93-CaMKII inhibitor, SM = SMP114-CaMKII inhibitor. Significance of inhibition was calculated compared to LPS stimulated sample with one-way ANOVA with Dunnett's post test: * p < 0.05, ** p < 0.01.

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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