Menstrual irregularity and bone mass in premenopausal women: Cross-sectional associations with testosterone and SHBG

Table 4 Association between quantitative ultrasound (QUS) measures and menstrual irregularity adjusted by each hormonal factor separately

	Adjusted model * β (95% CI)	Adjusted model + testosterone β (95% CI)	Adjusted model + SHBG β (95% CI)	Adjusted model +FAI β (95% CI)
BUA
Regular cycle	Ref	Ref	Ref	Ref
Irregular cycle	0.31 (-0.01, 0.64)	0.29 (-0.04, 0.61)	0.28 (-0.05, 0.61)	0.25 (-0.07, 0.58)
SOS
Regular cycle	Ref	Ref	Ref	Ref
Irregular cycle	0.38 (0.05, 0.71)	0.36 (0.03, 0.68)	0.31 (-0.02, 0.64)	0.30 (-0.03, 0.63)
QUI
Regular cycle	Ref	Ref	Ref	Ref
Irregular cycle	0.38 (0.05, 0.71)	0.36 (0.03, 0.68)	0.32 (-0.01, 0.65)	0.31 (-0.02, 0.63)

BUA = broadband ultrasound attenuation. SOS = speed of sound. QUI = quantitative ultrasound index. SHBG = sex hormone-binding globulin. FAI = free androgen index. QUS measures were log transformed before converted into standardized values. β = standardised beta coefficients. *Adjusted model controlled for age and BMI. Bolder denotes significant association (P < 0.05).

ISSN: 1471-2474