Enhancement of antinociception by coadminstration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis

Table 2 Percentage of change from baseline reaction latency times of C57BL/6 mice at 1 hour post-drug treatment in the hot plate test.

Drug and dose administered to mice	% Change in reaction latency (mean ± S.E.M of the values obtained from 7 to 9 animals.)^#	Statistical significance^§
Vehicles for indomethacin and minocycline	-8.62 ± 5.65 (n = 7)
Indomethacin 10 mg/kg	3.25 ± 6.05 (n = 8)	ns
Minocycline 50 mg/kg	-34.85 ± 3.88 (n = 8)	**
Indomethacin 10 + minocycline 50 mg/kg	32.74 ± 10.85 (n = 9)	**

^# (response latency after drug treatment - baseline latency)/baseline latency × 100.
^§Statistically significant differences in comparison with drug vehicle: ** p < 0.01; ns: no statically significant differences in comparison with drug vehicle (one-way ANOVA followed by Newman-Keuls test).

ISSN: 1471-2474