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Table 2 Percentage of change from baseline reaction latency times of C57BL/6 mice at 1 hour post-drug treatment in the hot plate test.

From: Enhancement of antinociception by coadminstration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis

Drug and dose administered to mice % Change in reaction latency (mean ± S.E.M of the values obtained from 7 to 9 animals.)# Statistical significance§
Vehicles for indomethacin and minocycline -8.62 ± 5.65 (n = 7)  
Indomethacin 10 mg/kg 3.25 ± 6.05 (n = 8) ns
Minocycline 50 mg/kg -34.85 ± 3.88 (n = 8) **
Indomethacin 10 + minocycline 50 mg/kg 32.74 ± 10.85 (n = 9) **
  1. # (response latency after drug treatment - baseline latency)/baseline latency × 100.
  2. §Statistically significant differences in comparison with drug vehicle: ** p < 0.01; ns: no statically significant differences in comparison with drug vehicle (one-way ANOVA followed by Newman-Keuls test).