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Table 2 Effects of a 16-week exercise program on clinical and laboratorial parameters related to inflammation, muscle damage, pain, disease activity, and quality of life in a 7-year-old patient with juvenile dermatomyositis (JDM) and in her unaffected monozygotic twin sister.

From: Responsiveness to exercise training in juvenile dermatomyositis: a twin case study

 

Healthy twin

JDM twin

Variable

Pre

Post

Pre

Post

CMAS

49

49

46

46

MMT

80

80

80

80

CHAQ

0

0

0

0

VAS (Physician's scale)

0

0

0

0

VAS (Parents' scale)

0

0

0

0

PGA

0

0

0

0

PaGA

0

0

0

0

CK (IU/L)

152

201

155

218

LDH (IU/L)

213

166

171

183

Aldolase (IU/L)

6

6

7

7

ESR (mm/hr)

12

15

20

20

C-reactive protein (mg/L)

0.32

0.79

1.73

0.70

  1. Abbreviations: CMAS = Childhood Muscle Assessment Scale; MMT = Manual Muscle Test; CHAQ = Childhood Health Assessment Questionnaire; VAS = Visual Analogic Score; PGA = Physician Global Assessment of Disease Activity; PaGA = Parents/Patient Global Assessment of Disease Activity; CK = Creatine kinase; LDH = Lactate Dehydrogenase; ESR = Erythrocyte Sedimentation Rate. Normal range for CK, LDH, aldolase, ESR and C-reactive protein are 24-192 IU/L, 141-237 IU/L, 1-7.4 IU/L, 0-20 mm/1st hr, 0-5 mg/L, respectively. Score range for CMAS, MMT, CHAQ, PGA and PaGA are 0-52, 0-80, 0-3, 0-10, 0-10, respectively.