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Table 3 Genes differentially expressed in OA meniscal cells compared to normal meniscal cells.

From: Analysis of meniscal degeneration and meniscal gene expression

Biological process Gene Name Gene ID Differ
Exp
(fold)*
Description
Immune response     
  HLA-DPA1 M27487 5.3 Major histocompatibility complex, class II, DP alpha 1
  IFI6 NM_022873 2.0 Interferon, alpha-inducible protein 6
  CFH X04697 1.7 Complement factor H
  CTSS NM_004079 1.6 Cathepsin S
  FYN S74774 1.5 FYN oncogene related to SRC, FGR, YES
  ILF2 NM_004515 -1.3 Interleukin enhancer binding factor 2, 45 kDa
  PSMB9 AI375915 -1.2 Proteasome (prosome, macropain) subunit, beta type, 9
Inflammatory
Response
    
  ITGB2 NM_000211 6.6 Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  CFH X04697 1.7 Complement factor H
  BDKRB2 NM_000623 1.3 Bradykinin receptor B2
Cytokine production     
  SRGN NM_002727 2.8 Serglycin
  ARNT AI768497 2.3 Aryl hydrocarbon receptor nuclear translocator
  INHBA M13436 1.9 Inhibin, beta A
Calcium ion transport     
  CACNA1C F11066 1.5 Calcium channel, voltage-dependent, L type, alpha 1C subunit
  FYN S74774 1.5 FYN oncogene related to SRC, FGR, YES
  CHRNB2 NM_000748 1.4 Cholinergic receptor, nicotinic, beta 2 (neuronal)
Biomineral formation     
  ENPP1 BF057080 1.7 Ectonucleotide pyrophosphatase/phosphodiesterase 1
  SRGN NM_002727 2.8 Serglycin
  ACVR2A AI149508 1.5 Activin A receptor, type IIA
Cell proliferation     
  ITGB2 NM_000211 6.6 Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  FGF7 NM_002009 4.1 Fibroblast growth factor 7 (keratinocyte growth factor)
  ELN AA479278 2.5 Elastin (supravalvular aortic stenosis, Williams-Beuren syndrome)
  IGFBP7 NM_001553 2.4 Insulin-like growth factor binding protein 7
  SKAP2 AB014486 2.2 Src kinase associated phosphoprotein 2
  ARNT AI768497 2.3 Aryl hydrocarbon receptor nuclear translocator
  FOXO1 NM_002015 1.5 Forkhead box O1
  BCAT1 AL390172 1.5 Branched chain aminotransferase 1, cytosolic
  ACVR2A AI149508 1.5 Activin A receptor, type IIA
  TCF7L2 AA664011 1.4 Transcription factor 7-like 2 (T-cell specific, HMG-box)
  CHRNB2 NM_000748 1.4 Cholinergic receptor, nicotinic, beta 2 (neuronal)
  TCFL5 NM_006602 1.2 Transcription factor-like 5 (basic helix-loop-helix)
  NRP1 AA609131 -1.3 Neuropilin 1
  PHB AL560017 -1.3 Prohibitin
  TBX5 NM_000192 -1.3 T-box 5
  NCK2 BC000103 -1.2 NCK adaptor protein 2
  PRPF19 NM_014502 -1.2 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
Integrin-mediated signaling pathway     
  ITGB2 NM_000211 6.6 Integrin, beta 2
  ITGB8 BF513121 3.6 Integrin, beta 8
  ITGA11 AF109681 1.5 integrin, alpha 11
  GAB2 NM_012296 1.5 GRB2-associated binding protein 2
Skeletal system/Tissue development     
  DSP NM_004415 5.2 Desmoplakin
  FGF7 NM_002009 4.2 Fibroblast growth factor 7 (keratinocyte growth factor)
  SRGN NM_002727 2.8 Serglycin
  INHBA M13436 1.9 Inhibin, beta A
  TIMP3 AW338933 1.7 TIMP metallopeptidase inhibitor 3
  ENPP1 BF057080 1.7 Ectonucleotide pyrophosphatase/phosphodiesterase 1
  COL5A1 N30339 1.7 Collagen, type V, alpha 1
  ACVR2A AI149508 1.5 Activin A receptor, type IIA
  FBN1 AW955612 1.4 Fibrillin 1
  BARX1 NM_021570N -1.9 BARX homeobox 1
  GABBR1 NM_001470 -1.9 Gamma-aminobutyric acid (GABA) B receptor, 1
  HOXA11 H94842 -1.5 Homeobox A11
  CHST11 NM_018413 -1.5 Carbohydrate (chondroitin 4) sulfotransferase 11
  NSDHL BC000245 -1.4 NAD(P) dependent steroid dehydrogenase-like
  ZNRD1 AF230337 -1.3 Zinc ribbon domain containing 1
  SMURF1 AF199364 -1.3 SMAD specific E3 ubiquitin protein ligase 1
DNA repair     
  ZSWIM7 BE645222 -1.6 Zinc finger, SWIM-type containing 7
  WDR33 AB044749 -1.5 WD repeat domain 33
  ASF1A NM_014034 -1.5 ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
  ATM U82828 -1.3 ataxia telangiectasia mutated
  PMS2L1 AI375694 -1.3 Postmeiotic segregation increased 2-like 1
  ALKBH2 AI865555 -1.2 AlkB, alkylation repair homolog 2 (E. coli)
  XRCC6 NM_001469 -1.2 X-ray repair complementing defective repair in Chinese hamster cells 6
  DCLRE1A D42045 -1.2 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)
  PRPF19 NM_014502 -1.2 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
  ELN AA479278 2.5 Elastin (supravalvular aortic stenosis, Williams-Beuren syndrome)
Cellular biosynthetic process     
  PITX2 NM_000325 -6.4 Paired-like homeodomain 2
  NR3C2 NM_000901 -5.8 Nuclear receptor subfamily 3, group C, member 2
  GALNT6 AW014155 -4.5 Polypeptide N-acetylgalactosaminyltransferase 6
  RGMB BE855765 -2.7 RGM domain family, member B
  FOXF2 NM_001452 -2.2 Forkhead box F2
  ZNF529 AL109722 -2.1 Zinc finger protein 529
  BARX1 NM_021570 -1.9 BARX homeobox 1
  DHODH M94065 -1.9 Dihydroorotate dehydrogenase
  LMO4 BC003600 -1.8 LIM domain only 4
  BRWD1 NM_018963 -1.7 Bromodomain and WD repeat domain containing 1
  TARS2 NM_025150 -1.7 Threonyl-tRNA synthetase 2, mitochondrial (putative)
  HLX M60721 -1.7 H2.0-like homeobox
  BNC2 AI767962 -1.7 Basonuclin 2
  PGD NM_002631 -1.6 Phosphogluconate dehydrogenase
  MEIS1 AL832770 -1.6 Meis homeobox 1
  ZNF420 AI339586 -1.6 Zinc finger protein 420
  ZFP28 AA831323 -1.5 Zinc finger protein 28 homolog (mouse)
  CARS2 NM_024537 -1.5 Cysteinyl-tRNA synthetase 2, mitochondrial (putative)
  HOXA11 H94842 -1.5 Homeobox A11
  PDLIM1 BC000915 13.2 PDZ and LIM domain 1 (elfin)
  ITGB2 NM_000211 6.6 Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  LMCD1 NM_014583 3.5 LIM and cysteine-rich domains 1
  KRT7 BC002700 3.1 Keratin 7
  ARNT AI768497 2.3 Aryl hydrocarbon receptor nuclear translocator
  ZNF415 NM_018355 2.2 Zinc finger protein 415
  ZNF630 AK000580 2.0 Zinc finger protein 630
  INHBA M13436 1.9 Inhibin, beta A
  GALNT1 U41514 1.7 Polypeptide N-acetylgalactosaminyltransferase 1
  ENPP1 BF057080 1.7 Ectonucleotide pyrophosphatase/phosphodiesterase 1
Miscellaneous     
  PTGES AF010316 3.2 Prostaglandin E synthase
  ADAMTS5 NM_007038 1.7 ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)
  DSP NM_004415 5.2 Desmoplakin
  FMOD NM_002023 2.7 Fibromodulin
  sFRP4 AW089415 3.4 Secreted frizzled-related protein 4
  MCAM M28882 2.3 Melanoma cell adhesion molecule
  TNXB NM_004381 -1.3 Tenascin XB
  FUS NM_004960 -1.5 Fusion (involved in t(12;16) in malignant liposarcoma)
  TBX5 NM_000192 -1.3 T-box 5
  1. *Positive number indicates elevated expression (fold) in OA meniscal cells compared to normal meniscal cells. Negative number indicates decreased expression (fold) in OA meniscal cells compared to normal meniscal cells.