Characteristic | Men | Women | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ā | Sample | Unilateral4 | Bilateral5 | Sample | Unilateral4 | Bilateral5 | ||||||||
Ā | Ā | % of outcome | OR | 95% CI | % of outcome | OR | 95% CI | Ā | % of outcome | OR | 95% CI | % of outcome | OR | 95% CI |
Smoking status | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āāāNever smoker | 526 | 6.6 | 1 | Ā | 6.0 | 1 | Ā | 1487 | 11.6 | 1 | Ā | 8.6 | 1 | Ā |
āāāFormer smoker | 1005 | 10.2 | 1.4 | 0.9-2.1 | 7.1 | 0.9 | 0.6-1.5 | 612 | 9.5 | 1.0 | 0.7-1.3 | 6.6 | 1.1 | 0.7-1.6 |
āāāOccasional smoker | 168 | 7.8 | 1.3 | 0.6-2.4 | 3.1 | 0.7 | 0.3-1.8 | 156 | 8.1 | 1.0 | 0.5-2.0 | 1.4 | 0.3 | 0.1-1.5 |
āāāCurrent smoker | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
< 10 pack-years | 255 | 10.3 | 1.5 | 0.9-2.4 | 5.3 | 0.9 | 0.4-1.7 | 218 | 9.8 | 1.1 | 0.7-1.9 | 3.3 | 0.7 | 0.3-1.7 |
10-20 pack-years | 152 | 7.6 | 1.2 | 0.5-2.4 | 2.6 | 0.5 | 0.1-1.9 | 175 | 7.1 | 0.8 | 0.4-1.7 | 8.7 | 1.8 | 1.0-3.1 |
> 20 pack-years | 349 | 13.6 | 1.9 | 1.3-2.9 | 4.6 | 0.7 | 0.4-1.4 | 162 | 6.3 | 0.6 | 0.3-1.2 | 4.0 | 0.6 | 0.3-1.4 |
Exercise (times/week) | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āāāā„ 1 | 1170 | 8.8 | 1 | Ā | 5.4 | 1 | Ā | 1281 | 9.6 | 1 | Ā | 8.0 | 1 | Ā |
āāā2-3 | 879 | 11.1 | 1.3 | 0.9-1.8 | 4.8 | 1.0 | 0.6-1.5 | 1050 | 10.6 | 1.1 | 0.8-1.5 | 5.9 | 0.8 | 0.5-1.1 |
āāāā¤ 4 | 697 | 7.0 | 0.7 | 0.5-1.1 | 6.6 | 1.0 | 0.6-1.6 | 893 | 9.5 | 0.9 | 0.6-1.2 | 6.2 | 0.7 | 0.4-1.0 |
Body mass index | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āāāNormal (18.5-24.9) | 967 | 7.7 | 1 | Ā | 4.3 | 1 | Ā | 1489 | 8.2 | 1 | Ā | 5.1 | 1 | Ā |
āāāUnderweight (< 18.5) | 13 | 0 | - | - | 0 | - | - | 46 | 3.7 | 0.4 | 0.1-2.0 | 2.3 | 0.4 | 0.1-3.5 |
āāāOverweight (25.0-29.9) | 1231 | 9.6 | 1.3 | 0.9-1.7 | 6.2 | 1.4 | 0.9-2.1 | 1011 | 11.6 | 1.2 | 0.9-1.6 | 7.1 | 1.1 | 0.7-1.5 |
āāāObese (ā„ 30.0) | 455 | 11.5 | 1.4 | 1.0-2.0 | 6.4 | 1.4 | 0.8-2.2 | 529 | 11.8 | 1.3 | 0.9-1.8 | 10.3 | 1.6 | 1.0-2.4 |
Waist circumference | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
Men: < 94.0 cm, Women: < 80 cm | 1053 | 6.1 | 1 | Ā | 4.7 | 1 | Ā | 918 | 6.5 | 1 | Ā | 2.8 | 1 | Ā |
Men: 94.0-101.9 cm | 802 | 10.9 | 1.8 | 1.2-2.5 | 5.5 | 1.1 | 0.7-1.7 | 798 | 10.5 | 1.5 | 1.1-2.1 | 6.2 | 1.9 | 1.2-3.2 |
Women: 80.0-87.9 cm | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
Men: ā„ 102.0 cm | 933 | 11.5 | 1.8 | 1.3-2.5 | 6.6 | 1.2 | 0.8-1.7 | 1580 | 11.3 | 1.4 | 0.99-2.0 | 10.1 | 2.5 | 1.6-4.0 |
Women: ā„ 88.0 cm | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
Waist-to-hip ratio1 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āāāNormal | 326 | 4.3 | 1 | Ā | 1.8 | 1 | Ā | 606 | 8.7 | 1 | Ā | 4.0 | 1 | Ā |
āāāIncreased | 1584 | 9.3 | 2.1 | 1.2-3.7 | 5.9 | 2.5 | 1.1-5.9 | 1858 | 9.0 | 0.9 | 0.6-1.2 | 5.8 | 1.0 | 0.6-1.6 |
āāāHigh | 878 | 11.2 | 2.4 | 1.3-4.4 | 6.4 | 2.4 | 1.0-5.8 | 831 | 12.3 | 1.0 | 0.7-1.5 | 12.3 | 1.8 | 1.1-3.1 |
Metabolic syndrome2 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āāāNo | 1945 | 8.0 | 1 | Ā | 5.2 | 1 | Ā | 2273 | 9.4 | 1 | Ā | 5.5 | 1 | Ā |
āāāYes | 842 | 12.5 | 1.5 | 1.2-1.9 | 6.2 | 1.0 | 0.7-1.5 | 1033 | 10.7 | 0.8 | 0.6-1.1 | 10.8 | 1.2 | 0.9-1.7 |
Insulin resistance3 | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
Mean, per each standard deviation increase | 2792 | Ā | 1.0 | 0.9-1.1 | Ā | 1.0 | 0.9-1.1 | 3318 | Ā | 1.1 | 0.9-1.3 | Ā | 1.1 | 0.9-1.3 |
Diabetes | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āāāNo | 2637 | 9.0 | 1 | Ā | 5.1 | 1 | Ā | 3135 | 9.5 | 1 | Ā | 6.7 | 1 | Ā |
āāāType 1 | 21 | 0 | - | Ā | 10.0 | 2.2 | 0.4-11.1 | 13 | 0 | - | Ā | 15.4 | 1.5 | 0.3-7.4 |
āāāType 2 | 144 | 16.1 | 1.7 | 1.0-2.9 | 13.3 | 1.9 | 0.98-3.6 | 177 | 16.3 | 1.3 | 0.8-1.9 | 13.8 | 1.3 | 0.7-2.2 |
C-reactive protein | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
āāāLow ā¤ 3 mg/L | 2339 | 8.8 | 1 | Ā | 5.4 | 1 | Ā | 2697 | 9.7 | 1 | Ā | 6.4 | 1 | Ā |
āāāHigh > 3 mg/L | 436 | 11.8 | 1.3 | 0.9-1.9 | 6.8 | 1.1 | 0.7-1.8 | 582 | 10.9 | 1.0 | 0.7-1.4 | 10.6 | 1.4 | 1.0-2.1 |
Carotid intima-media thickness | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā | Ā |
Mean IMT, per each standard deviation (0.23 mm) increase | 599 | Ā | 1.2 | 0.9-1.6 | Ā | 1.3 | 0.9-1.7 | 723 | Ā | 0.7 | 0.4-1.0 | Ā | 0.9 | 0.6-1.3 |