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Table 2 Histopathological scoring of joint sections

From: Supplementation of diet with krill oil protects against experimental rheumatoid arthritis

Parameter Score
Infiltrate  
No infiltrate detected. 0
Modest leukocyte infiltrate in synovial tissue, no fluid leukocytes. 1
Moderate leukocyte infiltrate in synovial tissue and in fluid phase with loss of synovial architecture. 2
Gross leukocyte infiltrate in synovial membrane and fluid space with significant loss of synovial and articular architecture. 3
Hyperplasia  
No abnormalities detected. 0
Synovial lining layer 2-4 cells thick. 1
Synovial lining layer >5 cells thick associated with moderate expansion of the sub lining layer zone. 2
Synovial lining layer >5 cells thick associated with significant expansion of the sub lining layer zone and potentially with loss of synovial architecture. 3
Erosion of cartilage/bone  
No abnormalities detected. 0
Fibrillation of cartilage and/or mild erosive infiltration of periosteal and subchondral bone. Nuclei intact within lacunae. 1
Moderate fibrillation and loss of cartilage and/or moderate erosive infiltration of periosteal and subchondral bone. Nuclei may show apoptosis within lacunae. 2
Significant loss of cartilage and/or erosive infiltration of periosteal and subchondral bone. Nuclei show apoptosis within lacunae across a wide area of cartilage/bone. 3