Table 2 Histopathological scoring of joint sections
From: Supplementation of diet with krill oil protects against experimental rheumatoid arthritis
Parameter | Score |
|---|---|
Infiltrate | Â |
No infiltrate detected. | 0 |
Modest leukocyte infiltrate in synovial tissue, no fluid leukocytes. | 1 |
Moderate leukocyte infiltrate in synovial tissue and in fluid phase with loss of synovial architecture. | 2 |
Gross leukocyte infiltrate in synovial membrane and fluid space with significant loss of synovial and articular architecture. | 3 |
Hyperplasia | Â |
No abnormalities detected. | 0 |
Synovial lining layer 2-4 cells thick. | 1 |
Synovial lining layer >5 cells thick associated with moderate expansion of the sub lining layer zone. | 2 |
Synovial lining layer >5 cells thick associated with significant expansion of the sub lining layer zone and potentially with loss of synovial architecture. | 3 |
Erosion of cartilage/bone | Â |
No abnormalities detected. | 0 |
Fibrillation of cartilage and/or mild erosive infiltration of periosteal and subchondral bone. Nuclei intact within lacunae. | 1 |
Moderate fibrillation and loss of cartilage and/or moderate erosive infiltration of periosteal and subchondral bone. Nuclei may show apoptosis within lacunae. | 2 |
Significant loss of cartilage and/or erosive infiltration of periosteal and subchondral bone. Nuclei show apoptosis within lacunae across a wide area of cartilage/bone. | 3 |