Safety and efficacy of duloxetine treatment in older and younger patients with osteoarthritis knee pain: a post hoc, subgroup analysis of two randomized, placebo-controlled trials
© Micca et al.; licensee BioMed Central Ltd. 2013
Received: 28 November 2012
Accepted: 12 April 2013
Published: 17 April 2013
Osteoarthritis (OA) knee pain is common in older patients and contributes to decreased quality of life. Older patients are generally at higher risk of adverse drug reactions due to age-related changes in physiology that affect drug disposition, metabolism, and response. These analyses examined efficacy and safety outcomes of older (≥65 years) versus younger patients from clinical trials of duloxetine in the management of OA knee pain.
This is a post hoc analysis of two 13-week studies, in which patients were randomized to duloxetine 60 mg/day or placebo. Both studies allowed potential dose changes after 7 weeks of dosing, with Study I re-randomizing duloxetine treated patients to either stay on 60 mg/day or increase to 120 mg/day; while Study II more closely mimicked clinical practice by escalating only non-responding patients to 120 mg/day. For all analyses patients were subgrouped by age: older (≥65 years) and younger (40–64 years). Overall efficacy and safety age-group comparisons of duloxetine versus placebo were performed using pooled data from both studies with all duloxetine dose levels combined. Safety analyses included discontinuation rates, treatment-emergent adverse events, and serious adverse events. To evaluate the effects of increasing the dose in non-responding patients, only Study II data were evaluated. Treatment arms were defined post hoc as placebo, duloxetine 60 mg/day, and duloxetine 60/120 mg/day.
At study end, patients in each age group who were treated with duloxetine versus placebo had significantly greater improvement in pain (both, p<.05), and there was no significant effect of age on treatment (p=.72). Increasing the dose to 120 mg in non-responding patients was not found to have a significant advantage. Among treatment-emergent adverse events with duloxetine treatment, only dizziness had a significantly differential treatment effect (p=.02) with greater incidence over placebo in younger patients (6.6% versus 0.6%, p=.02), but not in older patients (1.0% versus 3.2%, p=.29).
Duloxetine was efficacious and generally well tolerated for management of symptomatic knee OA in both older and younger patients, but increasing the dose to 120 mg in non-responding patients did not provide additional benefit.
KeywordsDuloxetine Osteoarthritis of the knee Older patients Pain
Osteoarthritis (OA) of the knee is the most common form of arthritis in older individuals and a leading cause of pain and disability , which contributes to overall decreased quality of life,  as well as the increased risk of depression and anxiety [3, 4]. Alleviation of pain symptoms is paramount in managing knee OA, and should be the focus of treatment . The approach to pain management in older patients may differ from that for younger patients, due to generally higher risk of adverse drug reactions from age-related changes in physiology that affect drug disposition, metabolism, and response . Since many adverse events are dose related, appropriate dosing for analgesic medications in this sensitive population is a particularly important clinical concern.
Prescription pain management options for OA knee pain include topical or oral non-steroidal anti-inflammatory drugs (NSAIDs), intra-articular injections of corticosteroids and hyaluronates, and opioids . NSAIDs and opioids are associated with potential use-limiting risks or side effects which may be heightened in the older patient . These effects include gastrointestinal bleeding, peptic ulcer disease, nephrotoxicity, and serious long term cardiovascular effects with NSAID use, and risks of sedation, respiratory depression, overdose, misuse, or dependency with opioids . When treating OA knee pain in older patients, it is important to have alternative treatment options that offer efficacy with an acceptable risk profile in this population.
Current evidence-based literature addressing the pharmacological management of chronic pain in older persons is sparse . As a result, algorithms for treatment are mostly generated from study outcomes in younger patients that are extrapolated to older individuals. Since clinical trials in OA knee pain often include patients ranging in age from 40 years to 65 years and older, analyzing treatment outcomes in age-stratified data may provide better clinical insight than extrapolations from younger to older patients.
In clinical studies, duloxetine (a selective, relatively balanced serotonin and norepinephrine reuptake inhibitor) has demonstrated efficacy in four distinct chronic pain conditions: diabetic peripheral neuropathic pain [9, 10], fibromyalgia [11, 12], chronic low back pain [13, 14], and OA knee pain [15, 16]. Since the OA knee pain trials included many older patients, we conducted a post hoc analysis of those trials to examine any differential effect of age on the efficacy and safety of duloxetine. In addition, we examined data that might suggest appropriate dosing of duloxetine in this population. In a recently published study, Abou-Raya et al.  reported that duloxetine 60 mg/day significantly improved pain as compared with placebo in older patients with OA knee pain, many of whom also had comorbid depression. Our post hoc analysis differs from that study in that the patients in our studies were not depressed, thereby allowing determination of the direct analgesic effect of duloxetine without confounding by improvement in depression. Furthermore, we compared treatment outcomes between older and younger patients, and investigated the utility of increasing the dose in non-responding patients.
Data were from two published 13-week, randomized, placebo-controlled studies in male and female outpatients who were at least 40 years of age, and met American College of Rheumatology clinical and radiographic criteria for the diagnosis of OA of the knee [15, 16]. In both studies, pain was assessed daily using an ordinal 11-point numerical rating scale (0 to 10) that was recorded in patient diaries. Efficacy assessments were based on the weekly mean of the daily average pain severity from these patient diaries. Pain was also assessed with the Brief Pain Inventory (BPI)  (severity range: 0–10) at weeks 4, 7, and 13. All patients provided written informed consent before the commencement of any study procedures.
For both studies, patients were required to have pain for ≥14 days of each month for 3 months prior to study entry, with a mean pain severity ≥4 on daily pain diary ratings during the screening and baseline periods. In addition, patients had to agree to maintain their usual activity level throughout the course of the study. Key exclusion criteria for both studies included having a body mass index >40 kg/m2; a diagnosis of inflammatory arthritis or an autoimmune disorder; having received invasive therapies within the prior 3 months, or joint replacement to the knee; being non-ambulatory or needing assistance walking with crutches or walker; any serious medical condition or psychiatric disorder, including major depressive disorder, as identified by the Mini International Neuropsychiatric Interview  that could compromise participation in the study.
Patients were randomly assigned 1:1 in double-blind fashion to treatment with duloxetine 60 mg/day or placebo as determined by a computer-generated random sequence using an Interactive Voice Response System (IVRS). All patients randomized to duloxetine were started on 30 mg/day for one week then escalated to 60 mg/day. After 7 weeks, the duloxetine dosing regimen could change. In Study I , patients in the duloxetine group were re-randomized via IVRS without regards to change in pain severity to either continue duloxetine 60 mg/day or to have their dose increased directly to 120 mg/day, and were continued on that dose for the remainder of the study. In Study II , patients in the duloxetine group who had <30% reduction from baseline in pain severity on the BPI 24-h average pain severity scale, had their dose increased directly to 120 mg/day and continued on that dose for the remainder of the study.
For this post hoc analysis, two patient groups were defined by their age at study entry: older patients were at least 65 years of age, and younger patients were less than 65. For the efficacy and safety analyses comparing duloxetine with placebo within age groups, studies were pooled and doses were pooled. In addition, a subgroup analysis was conducted to determine the efficacy of duloxetine in the “oldest of the old” (>75 years) as compared with the “younger of the old” (65 to <75 years) patients. For comparing the effect of increasing duloxetine to 120 mg in non-responding patients, only data from Study II were evaluated as it most closely reflected clinical practice; whereas re-randomization to a higher dose does not. Treatment arms were defined post hoc as placebo, duloxetine 60 mg/day (patients who remained on 60 mg for the entire study), and duloxetine 60/120 mg/day (patients who received 60 mg for 7 weeks, followed by duloxetine 120 mg for 6 weeks). Safety assessments included spontaneously reported treatment-emergent adverse events (TEAEs), discontinuation rates due to TEAEs, serious adverse events (SAEs), and treatment-emergent abnormal vital signs.
Categorical baseline characteristics were compared between age groups using a logistic regression model with terms for study, treatment, age group and the treatment-by-age group interaction. Quantitative baseline characteristics were compared using an analysis of variance model with similar explanatory terms. Weekly means of change from baseline in the average pain severity ratings from patient diaries were analyzed using a likelihood-based, mixed-effects model repeated measures (MMRM) approach that used all available observations. The model included the fixed categorical effects of site, treatment, week, age group, treatment-by-week interaction, age group-by-week interaction, treatment-by-age group interaction, treatment-by-age-group-by-week interaction, as well as the continuous fixed covariates of baseline score and baseline-by-week interaction.
The analysis of completion rates, discontinuation rates due to adverse events (AEs), and incidence of spontaneously reported TEAEs and SAEs were compared using a logistic regression model with terms for study, treatment, age category, and the treatment-by-age interaction. For comparison among treatment groups and age groups, test results were considered statistically significant if p≤.05; for tests of interaction, results were considered statistically significant if p≤.1. Statistical analyses were performed using SAS, version 9.1 (SAS Institute, Inc, Cary, NC).
Baseline demographics and illness characteristics
Older versus younger
Age in years, mean (SD)
Female, n (%)
Caucasian, n (%)
OA duration, years, mean (SD)
OA pain, years. mean (SD)
BMI (kg/m2), mean (SD)
Pain diary ratings, mean (SD)
BPI, mean (SD)
NSAID use, n (%)a
Study completion rates did not differ between age groups (p=.69), but significantly more patients treated with placebo versus duloxetine completed the study (older, 84.9% versus 70.9%; younger, 83.1% versus 71.3%; p<.001). There was no significant treatment-by-age group interaction in rates of discontinuation due to adverse events (p=.74), but the rate was significantly greater in patients treated with duloxetine versus placebo (older, 22.3% versus 7.5%; younger, 11.8% versus 4.5%; p<.001), and was significantly greater in older versus younger patients (p=.05). AEs that were reasons for discontinuation in the older group treated with duloxetine included: arthralgia (n=2), asthenia (n=3), nausea (n=4), and one incident for each of these: abnormal dreams, anxiety, bronchitis, diarrhea, drug intolerance, ejaculation disorder, erectile dysfunction, flatulence, headache, hypercreatinemia, insomnia, migraine, rash, and supraventricular tachycardia. In the younger group, patients treated with duloxetine discontinued due to nausea (n=3), and n=1 for each of the following: anxiety, condition aggravated, constipation, dizziness, dyspepsia, fatigue, hemorrhoids, hot flush, insomnia, memory impairment, palpitations, sleep disorder, and somnolence.
Treatment-emergent adverse events (TEAE) occurring in at least 5% of patients who received duloxetine
Placebo N=94 n (%)
Duloxetine N=103 n (%)
Placebo N=154 n (%)
Duloxetine N=136 n (%)
Treatment-by-Age Group Interaction p values
Patients with at least one TEAE
Patients with at least one SAE
The frequency of SAEs did not differ significantly between age or treatment groups and there was no significant treatment-by-age interaction (Table 2). SAEs reported by older patients who received duloxetine (n=1 for each) included: asthma, bronchitis, drug intolerance, rhinitis allergic, and supraventricular tachycardia. Older patients in the placebo group reported atrial fibrillation (n=1), and myocardial infarction (n=1). SAEs in younger patients treated with duloxetine included memory impairment (n=1), younger patients treated with placebo reported dehydration (n=1) and gouty arthritis (n=1). There were no SAEs that occurred in either older or younger patients after escalation to the 120 mg dose of duloxetine. No deaths occurred in either study.
Treatment-emergent vital sign abnormalities
Placebo n (%)
Duloxetine n (%)
Placebo n (%)
Duloxetine n (%)
Treatment-by-Age Group Interaction p values
PCS Weight gain
PCS Weight loss
This post hoc analysis did not find a differential effect of age on duloxetine treatment in non-depressed patients with OA knee pain. This is an important finding as it suggests that duloxetine is efficacious in the treatment of OA knee pain regardless of age. The lack of an age effect on pain reduction in this patient population is supported by similar findings in a post hoc age-stratified subgroup analysis of duloxetine in the treatment of diabetic peripheral neuropathic pain .
In both older and younger patients, treatment with duloxetine 60 mg/day was associated with significantly greater pain reduction as compared to placebo. However, increasing the dose of duloxetine in older and younger patients, who were not experiencing adequate pain reduction, was not found to provide additional benefit. These findings may be particularly relevant to the treatment of older patients to avoid unnecessary dose escalation.
Overall, duloxetine was generally well tolerated by patients in each age group, considering that rates of completion and discontinuation due to adverse events did not differ significantly or show a tendency toward more drop outs in the older population, and were similar to findings in other studies across indications. Further, adverse events with duloxetine generally did not differ between age groups except that dizziness was associated with greater risk among younger patients relative to older ones. While orthostatic hypotension was the most common treatment-emergent vital sign abnormality reported in each age and treatment group, there was no significant treatment-by-age group interaction.
The interpretation of this post hoc analysis has limitations to be considered. First, neither study was specifically designed to assess safety or efficacy in exclusively older patients. Furthermore, the results of subgroup analyses should generally be interpreted with caution due to concerns about multiple testing and increased likelihood of finding potentially spurious and un-reproducible results .
Duloxetine 60 mg was efficacious for managing OA knee pain in both age groups, but increasing the dose to 120 mg in non-responding patients did not provide additional benefit. There was no consistent signal indicating that the safety of duloxetine might differ significantly between older and younger patients.
Presented at the American College of Rheumatology ACR/ARHP annual scientific sessions; Chicago, IL, USA; November 5–9, 2011.
- Lawrence RC, Helmick CG, Arnett FC, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Liang MH, Pillemer ST, Steen VD, Wolf F: Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998, 41: 778-799. 10.1002/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V.View ArticlePubMedGoogle Scholar
- Skevington SM: Investigating the relationship between pain and discomfort and quality of life, using the WHO-QOL. Pain. 1998, 76: 395-406. 10.1016/S0304-3959(98)00072-4.View ArticlePubMedGoogle Scholar
- Axford J, Heron C, Ross F, Victor CR: Management of knee osteoarthritis in primary care: pain and depression are the major obstacles. J Psychosom Res. 2008, 64: 461-467. 10.1016/j.jpsychores.2007.11.009.View ArticlePubMedGoogle Scholar
- Bair MJ, Wu J, Damush TM, Sutherland JM, Kroenke K: Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients. Psychosom Med. 2008, 70 (8): 890-897. 10.1097/PSY.0b013e318185c510.View ArticlePubMedPubMed CentralGoogle Scholar
- Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P: OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthr Cartilage. 2008, 16: 137-162. 10.1016/j.joca.2007.12.013.View ArticleGoogle Scholar
- Fine PG: Pharmacological management of persistent pain in older patients. Clin J Pain. 2004, 20: 220-226. 10.1097/00002508-200407000-00003.View ArticlePubMedGoogle Scholar
- Fitzcharles MA, Lussier D, Shir Y: Management of chronic arthritis pain in the elderly. Drugs Aging. 2010, 27: 471-490. 10.2165/11536530-000000000-00000.View ArticlePubMedGoogle Scholar
- Ickowicz E: Pharmacological management of persistent pain in older persons. J Am Geriatr Soc. 2009, 57: 1331-1346.View ArticleGoogle Scholar
- Raskin J, Pritchett YL, Wang F, D'Souza DN, Waninger AL, Iyengar S, Wernicke JF: A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain. Pain Med. 2005, 6: 346-356. 10.1111/j.1526-4637.2005.00061.x.View ArticlePubMedGoogle Scholar
- Wernicke JF, Pritchett YL, D'Souza DN, Waninger A, Tran P, Iyengar S, Raskin J: A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain. Neurology. 2006, 67: 1411-1420. 10.1212/01.wnl.0000240225.04000.1a.View ArticlePubMedGoogle Scholar
- Arnold LM, Lu Y, Crofford LJ, Wohlreich M, Detke MJ, Iyengar S, Goldstein DJ: A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder. Arthritis Rheum. 2004, 50: 2974-2984. 10.1002/art.20485.View ArticlePubMedGoogle Scholar
- Russell JI, Mease PJ, Smith TR, Kajdasz DK, Wohlreich MM, Detke MJ, Walker DJ, Chappell AS, Arnold LM: Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial. Pain. 2008, 136: 432-444. 10.1016/j.pain.2008.02.024.View ArticlePubMedGoogle Scholar
- Skljarevski V, Ossanna MJ, Liu-Seifert H, Zhang Q, Chappell A, Iyengar S, Detke M, Backonja M: A double-blind, randomized trial of duloxetine versus placebo in the management of chronic low back pain. Eur J Neurol. 2009, 16: 1041-1048. 10.1111/j.1468-1331.2009.02648.x.View ArticlePubMedGoogle Scholar
- Skljarevski V, Zhang S, Desaiah D, Alaka KJ, Palacios S, Miazgowski T, Patrick K: Duloxetine versus placebo in patients with chronic low back pain: a 12-week, fixed dose, randomized, double-blind trial. J Pain. 2010, 11 (12): 1282-1290. 10.1016/j.jpain.2010.03.002.View ArticlePubMedGoogle Scholar
- Chappell AS, Ossanna MJ, Liu-Seifert H, Iyengar S, Skljarevski V, Li LC, Bennett RM, Collins H: Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial. Pain. 2009, 146: 253-260. 10.1016/j.pain.2009.06.024.View ArticlePubMedGoogle Scholar
- Chappell AS, Desaiah D, Liu-Seifert H, Zhang S, Skljarevski V, Belenkov Y, Brown JP: A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment chronic pain due to osteoarthritis of the knee. Pain Pract. 2011, 11 (1): 33-41. 10.1111/j.1533-2500.2010.00401.x.View ArticlePubMedGoogle Scholar
- Abou-Raya S, Abou-Raya A, Helmi M: Duloxetine for the management of pain in older adults with knee osteoarthritis: randomised placebo-controlled trial. Age Aging. 2012, 41 (5): 646-652. 10.1093/ageing/afs072.View ArticleGoogle Scholar
- Cleeland CS, Ryan KM: Pain assessment: global use of the brief inventory. Ann Acad Med Singapore. 1994, 23: 129-138.PubMedGoogle Scholar
- Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Herqueta T, Baker R, Dunbar GC: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998, 59 (Suppl 20): 22-33.PubMedGoogle Scholar
- Wasan AD, Ossanna MJ, Raskin J, Wernicke JF, Robinson MJ, Hall JA, Edwards SE, Lipsius S, Meyers AL, McCarberg BH: Safety and efficacy of duloxetine in the treatment of diabetic peripheral neuropathic pain in older patients. Curr Drug Saf. 2009, 4: 22-29. 10.2174/157488609787354404.View ArticlePubMedGoogle Scholar
- Wang R, Lagakos SW, Ware JH, Hunter DJ, Drazen JM: Statistics in medicine – reporting of subgroup analyses in clinical trials. N Engl J Med. 2007, 357: 2189-2194. 10.1056/NEJMsr077003.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2474/14/137/prepub
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