Table 3 Multivariate analysis of severity of disability (HAQ-DI), quality of life (EQ-5D) and severity of depression (PHQ-9) and fatigue (FACIT-F)
HAQ-DI | EQ-5D | PHQ-9 score | FACIT-F | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
coef. | (95% CI) | P value | coef. | (95% CI) | P value | coef. | (95% CI) | P value | coef. | (95% CI) | P value | |
Diagnosis: CSA | ||||||||||||
UA | 0.03 | (-0.12, 0.17) | 0.72 | -0.02 | (-0.08, 0.05) | 0.61 | -0.70 | (-2.16, 0.75) | 0.34 | 1.54 | (-1.28, 4.36) | 0.29 |
RA | 0.03 | (-0.11, 0.17) | 0.65 | 0.03 | (-0.03, 0.09) | 0.36 | -0.42 | (-1.81, 0.97) | 0.55 | 0.97 | (-1.72, 3.67) | 0.48 |
Sex: Male | ||||||||||||
Female | 0.13 | (0.03, 0.21) | 0.01 | -0.02 | (-0.07, 0.02) | 0.29 | 0.85 | (-0.16, 1.85) | 0.10 | -3.64 | (-5.59, -1.70) | < 0.001 |
Age: 18–39 years | ||||||||||||
40–49 | -0.02 | (-0.17, 0.12) | 0.75 | 0.03 | (-0.03, 0.10) | 0.27 | -0.19 | (-1.59, 1.22) | 0.79 | 0.61 | (-2.11, 3.33) | 0.66 |
50–59 | 0.03 | (-0.11, 0.17) | 0.66 | 0.02 | (-0.04, 0.08) | 0.54 | -0.43 | (-1.79, 0.92) | 0.53 | 2.02 | (-0.59, 4.64) | 0.13 |
≥ 60 | 0.13 | (-0.01, 0.27) | 0.07 | 0.04 | (-0.02, 0.10) | 0.19 | -2.47 | (-3.85, -1.09) | < 0.001 | 5.05 | (2.37, 7.73) | < 0.001 |
Body Mass Index: <25 kg/m2 | ||||||||||||
25–30 kg/m2 | 0.06 | (-0.06, 0.18) | 0.29 | -0.03 | (-0.08, 0.02) | 0.24 | 1.26 | (0.08, 2.45) | 0.04 | -2.42 | (-4.71, -0.13) | 0.04 |
≥ 30 kg/m2 | 0.08 | (-0.04, 0.20) | 0.17 | -0.03 | (-0.08, 0.03) | 0.34 | 1.41 | (0.22, 2.60) | 0.02 | -2.38 | (-4.68, -0.08) | 0.04 |
Index of Multiple Deprivation: 3rd quintile | ||||||||||||
1st (most deprived) | 0.23 | (0.10, 0.36) | 0.001 | -0.03 | (-0.08, 0.03) | 0.35 | 1.89 | (0.59, 3.18) | 0.004 | -2.60 | (-5.11, 0.09) | 0.04 |
2nd | 0.17 | (0.02, 0.32) | 0.03 | -0.01 | (-0.08, 0.05) | 0.71 | 0.21 | (-1.27, 1.70) | 0.78 | 0.12 | (-2.75, 3.00) | 0.93 |
4th | 0.19 | (-0.01, 0.39) | 0.05 | 0.01 | (-0.07, 0.10) | 0.76 | -1.08 | (-3.01, 0.85) | 0.27 | 1.19 | (-2.54, 4.93) | 0.53 |
5th (least deprived) | 0.05 | (-0.17, 0.26) | 0.68 | 0.03 | (-0.07, 0.12) | 0.57 | 0.01 | (-2.09, 2.12) | 0.99 | 0.22 | (-3.86, 4.29) | 0.92 |
Disease activity (DAS-28): Remission | ||||||||||||
Low (≥ 2.6 to 3.2) | 0.18 | (< 0.01, 0.36) | 0.05 | -0.16 | (-0.23, -0.08) | < 0.001 | 0.86 | (-0.89, 2.61) | 0.34 | -0.42 | (-3.81, -2.97) | 0.81 |
Moderate (≥ 3.2 to ≤ 5.1) | 0.59 | (0.44, 0.73) | < 0.001 | -0.23 | (-0.29, -0.17) | < 0.001 | 4.25 | (2.79, 5.71) | < 0.001 | -8.15 | (-10.98, -5.31) | < 0.001 |
High (> 5.1) | 1.16 | (0.98, 1.33) | < 0.001 | -0.44 | (-0.52, -0.37) | < 0.001 | 7.35 | (5.59, 9.12) | < 0.001 | -15.02 | (-18.44, -11.61) | < 0.001 |
Polypharmacy: <5 drugs | ||||||||||||
≥ 5 drugs | 0.23 | (0.11, 0.34) | < 0.001 | -0.10 | (-0.15, -0.05) | < 0.001 | 1.64 | (0.49, 2.79) | 0.005 | -3.43 | (-5.66, -1.20) | 0.003 |
Constant term | -0.01 | (-0.16, 0.22) | 0.82 | (0.74, 0.91) | 3.07 | (1.13, 5.02) | 42.21 | (40.36, 46.78) | ||||